COMPARISON OF INTRINSIC CONNECTIVITY IN DIFFERENT AREAS OF MACAQUE MONKEY CEREBRAL-CORTEX
COMPARISON OF INTRINSIC CONNECTIVITY IN DIFFERENT AREAS OF MACAQUE MONKEY CEREBRAL-CORTEX
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DOI：
10.1093/cercor/3.2.148
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发表时间：
1993-03-01
期刊：
影响因子：
3.7
通讯作者：
LEVITT, JB
中科院分区：
文献类型：
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作者：
LUND, JS;YOSHIOKA, T;LEVITT, JB
我们使用小量生物胞素注射来标记和比较猕猴大脑皮层多个区域中锥体神经元的区域内横向扩散投影的模式。在视觉区（V1、V2 和 V4）、体感区（3b、1 和 2）和运动区 4 中，表层注射直径 200 微米的生物胞素，形成点状不连续连接模式。在前额皮质（区域 9 和 46）中，观察到条纹状连接模式。在检查的所有皮层区域中，无末端间隙的宽度与末端斑块的平均直径或末端条纹的宽度密切相关。此外，斑块和间隙尺寸都与同一皮质区域浅层中单个锥体神经元树突域的平均横向扩展相匹配。尽管皮质区域和不同物种的规模存在双重差异，但连接马赛克的这些建筑特征是恒定的。因此，它们似乎是皮质组织的基本特征。提供了一种模型，其中与兴奋性锥体神经元同时激活的局部回路抑制性“篮子”中间神经元可以否决圆形或条纹状区域内的锥体神经元连接；这可能导致本研究中观察到的横向连接模式的形成，并为大脑皮层功能的进一步理论研究提供框架。
We have used small injections of biocytin to label and compare patterns of intraareal, laterally spreading projections of pyramidal neurons in a number of areas of macaque monkey cerebral cortex. In visual areas (V1, V2, and V4), somatosensory areas (3b, 1, and 2), and motor area 4, a punctate discontinuous pattern of connections is made from 200-mum-diameter biocytin injections in the superficial layers. In prefrontal cortex (areas 9 and 46), stripe-like connectivity patterns are observed. In all areas of cortex examined, the width of the terminal-free gaps is closely scaled to the average diameter of terminal patches, or width of terminal stripes. In addition, both patch and gap dimensions match the average lateral spread of the dendritic field of single pyramidal neurons in the superficial layers of the same cortical region. These architectural features of the connectional mosaics are constant despite a twofold difference in scale across cortical areas and different species. They therefore appear to be fundamental features of cortical organization. A model is offered in which local circuit inhibitory ''basket'' interneurons, activated at the same time as excitatory pyramidal neurons, could veto pyramidal neuron connections within either circular or stripe-like domains; this could lead to the formation of the pattern of lateral connections observed in this study, and provides a framework for further theoretical studies of cerebral cortex function.