Progressive histopathologic abnormalities in the persistent generalized lymphadenopathy syndrome.
Progressive histopathologic abnormalities in the persistent generalized lymphadenopathy syndrome.
复制标题
持续性全身淋巴结病综合征的进行性组织病理学异常。
DOI：
10.1097/00000478-198708000-00006
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Meyer,PR
中科院分区：
文献类型：
--
作者：
Turner,RR;Levine,AM;Gill,PS;Parker,JW;Meyer,PR
采用定量分类，我们评估了20例持续性全身淋巴结病（PGL）的同性恋男性的连续淋巴结活检，并将结果与外周血淋巴细胞计数和临床表现相关联。在19个月的中位随访间隔中，10例患者（50%）从一种组织学亚型进展到另一种。其他10例患者的淋巴结在最近的标本中也表现出组织化滤泡数量减少，以及其他组织学参数和外周血T4计数的进行性异常。这表明这些患者没有稳定的疾病。然而，在19个月的中位随访间隔中，只有一名（5%）患者发展为艾滋病。我们的结论是，进行性淋巴结组织病理学亚型与T4淋巴细胞计数下降或短时间内的临床病程没有很好的相关性。
Using a quantitative classification, we evaluated serial lymph node biopsies in 20 homosexual men with Persistent Generalized Lymphadenopathy (PGL), and correlated the results with peripheral blood lymphocyte counts and clinical findings. In a median follow-up interval of 19 months, ten patients (50%) had progression from one histologic subtype of this disorder to another. Lymph nodes from the other 10 patients also demonstrated decreased numbers of organized follicles in the most recent specimens, in addition to progressive abnormalities of other histologic parameters and peripheral blood T4 counts. This suggests that these patients do not have stable disease. However, in a median follow-up interval of 19 months, only one (5%) of the patients had developed AIDS. We conclude that progressive lymph node histopathologic subtypes do not correlate well with decreased T4 lymphocyte counts or clinical course over a short time interval.