Effects of magnesium on postprandial serum lipid responses in healthy human subjects
Effects of magnesium on postprandial serum lipid responses in healthy human subjects
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DOI：
10.1017/s0007114509992716
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发表时间：
2010-02-28
影响因子：
3.6
通讯作者：
Kondo, Kazuo
中科院分区：
文献类型：
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作者：
Kishimoto, Yoshimi;Tani, Mariko;Kondo, Kazuo
餐后高脂血症已被认为是动脉粥样硬化发展的危险因素。流行病学和动物研究表明，镁的摄入量与动脉粥样硬化的一些危险因素呈负相关，包括脂代谢。本研究旨在探讨补镁对血脂水平餐后反应的影响。我们用卤水(在日语中是nigari)，一种从海水或盐湖水中提取的天然氯化镁溶液来补充镁。在这项双向、随机、交叉的研究中，16名健康的男性志愿者食用了30克黄油，加或不加含500毫克镁的5毫升卤水。分别于服药后2、3、4、6h采空腹和餐后血样。用血清标记物、乳糜粒标记物、载脂蛋白B48、残留物样颗粒胆固醇(RLP-C)和NEFA浓度评价餐后血脂反应。我们发现，补充镁可以降低和延迟脂肪负荷后的血清和乳糜粒标签反应。载脂蛋白B48浓度差异有统计学意义(P
Postprandial hyperlipidaemia has been recognised to be a risk factor for atherosclerosis development. Epidemiological and animal studies have shown that Mg intake is inversely associated with some risk factors of atherosclerosis, including lipid metabolism. The present study was performed to determine the effects of Mg supplementation on postprandial responses in serum lipid levels. We used bittern (Nigari, in Japanese), a natural MgCl2 Solution from sea or salt lake water, for Mg Supplementation. In it two-way, randomised, crossover study, sixteen healthy male Volunteers consumed 30g butter with or without 5 ml bittern containing 500 mg of Mg. Fasting and postprandial blood samples were taken 2, 3, 4 and 6 h after ingestion. Postprandial lipid responses were evaluated by serum TAG, chylomicron TAG, apo-B48, remnant-like particle cholesterol (RLP-C) and NEFA concentrations. We found that the serum and the chylomicron TAG responses after the fat load were reduced and delayed by Mg supplementation. The concentrations of apo-B48 (P