Fluorescence tomographic imaging using a handheld-probe-based optical imager: extensive phantom studies.
Fluorescence tomographic imaging using a handheld-probe-based optical imager: extensive phantom studies.
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DOI：
10.1364/ao.48.006408
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发表时间：
2009-11-20
期刊：
影响因子：
1.9
通讯作者：
Godavarty A
中科院分区：
文献类型：
--
作者：
Ge J;Erickson SJ;Godavarty A
基于手持探头的光学成像仪由于其潜在的便携性和最大的患者舒适性而在乳房成像中很受欢迎。最近，一种新型的基于手持探头的光学成像仪被开发出来，并论证了其用于三维荧光层析成像的可行性。在这里，为了评估手持成像仪的性能极限，对大型平板体模(650毫升)进行了广泛的断层成像研究。实验使用不同的目标体积(0.1-0.45cc)、目标深度(1-3 cm)和荧光(吲哚青绿)吸收对比度，在非荧光(1：0)和恒定的荧光背景(1000：1-5：1)中进行。估计手持成像仪的灵敏度和特异度分别为43%和95%。
Hand-held probe based optical imagers are popular towards breast imaging due to their potential portability and maximum patient comfort. Recently, a novel hand-held probe based optical imager has been developed and its feasibility for three-dimensional fluorescence tomographic imaging demonstrated. Herein, extensive tomography studies were performed on large slab phantoms (650 ml) in order to assess the performance limits of the hand-held imager. Experiments were performed using different target volumes (0.1–0.45 cc), target depths (1–3 cm), and fluorescence (Indocyanine Green) absorption contrast ratios in a non-fluorescing (1:0) and constant fluorescing backgrounds (1000:1-5:1). The estimated sensitivity and specificity of the hand-held imager is 43% and 95%, respectively.