Toward the unknown: consciousness and pain.
Toward the unknown: consciousness and pain.
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DOI：
10.1093/nc/niad002
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发表时间：
2023
影响因子：
4.1
通讯作者：
中科院分区：
文献类型：
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作者：
大脑的复杂性阻碍了对意识的研究，但研究一种感觉的意识是可能的，即疼痛。有三个系统是体验疼痛所必需的：躯体感觉系统向丘脑传达关于损伤的信息，丘脑意识到损伤，但不知道疼痛。丘脑将信息分配给情感系统和认知系统，情感系统调节疼痛的强度，认知系统对疼痛给予注意。对疼痛患者和那些经历安慰剂和催眠诱导镇痛的患者的成像显示，疼痛和注意力的两个基本皮层回路位于前扣带皮层内。当高频输入导致锥体神经元的顶树突上的突触处的长时程增强（LTP）的发展时，该回路被激活。LTP通过α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）和N-甲基-D-天冬氨酸（NMDA）受体起作用，并且前扣带皮层特异性1型腺苷酸环化酶对于LTP和疼痛都是必需的。顶端树突形成广泛的网络，使得来自严重损伤的输入导致局部场电位的出现。使用小鼠模型，我提出的实验设计来测试的假设，即局部场电位是必要的和足够的疼痛意识。
Studies of consciousness are hindered by the complexity of the brain, but it is possible to study the consciousness of a sensation, namely pain. Three systems are necessary to experience pain: the somatosensory system conveys information about an injury to the thalamus where an awareness of the injury but not the painfulness emerges. The thalamus distributes the information to the affective system, which modulates the intensity of the pain, and to the cognitive system that imparts attention to the pain. Imaging of patients in pain and those experiencing placebo and hypnosis-induced analgesia shows that two essential cortical circuits for pain and attention are located within the anterior cingulate cortex. The circuits are activated when a high-frequency input results in the development of a long-term potentiation (LTP) at synapses on the apical dendrites of pyramidal neurons. The LTP acts via α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors, and an anterior cingulate cortex–specific type-1 adenylate cyclase is necessary for both the LTP and the pain. The apical dendrites form an extensive network such that the input from serious injuries results in the emergence of a local field potential. Using mouse models, I propose experiments designed to test the hypothesis that the local field potential is necessary and sufficient for the consciousness of pain.
DOI：
10.1016/j.ynpai.2021.100081
发表时间：
2022-01
期刊：
Neurobiology of pain (Cambridge, Mass.)
影响因子：
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作者：
Shiers S;Elahi H;Hennen S;Price TJ
通讯作者：
Price TJ