CHRONIC DISEASE IN FORMER COLLEGE-STUDENTS .17. SOCIOCULTURAL MOBILITY AS A PRECURSOR OF CORONARY HEART-DISEASE AND HYPERTENSION
CHRONIC DISEASE IN FORMER COLLEGE-STUDENTS .17. SOCIOCULTURAL MOBILITY AS A PRECURSOR OF CORONARY HEART-DISEASE AND HYPERTENSION
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DOI：
10.1093/oxfordjournals.aje.a112622
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发表时间：
1978-01-01
影响因子：
5
通讯作者：
PAFFENBARGER, RS
中科院分区：
文献类型：
--
作者：
GILLUM, RF;PAFFENBARGER, RS
在1939-1950年对13，728名前哈佛大学[美国]学生进行的队列研究中，研究了社会文化流动性与随后的冠心病（CHD）和高血压（HT）之间的关系。所有13,728人都被随访了冠心病死亡率，而8852人在1962年或1966年和1972年返回了自行填写的邮件问卷，询问医生诊断的心肌梗死（MI）、心绞痛（AP）和HT。随机选择冠心病98例、心肌梗死78例、急性胰腺炎48例各4例作为对照。为319例HT病例中的每例选择一个对照。在单变量分析中，父亲的职业状况与合并致死性CHD和MI的风险之间以及地理流动性与HT的风险之间存在显著的负相关。这些相关性在通过个体混杂因素和多变量混杂因素汇总评分进行分层后仍然存在。代际流动性，如父亲的职业地位所示，与1.5倍。增加致死性CHD和MI的风险。代际间的地理流动性与HT风险的轻微降低有关。
The relationship between sociocultural mobility and subsequent coronary heart disease (CHD) and hypertension (HT) was studied in a cohort of 13,728 male former Harvard University [USA] students examined in 1939-1950. All 13,728 were followed for CHD mortality, while 8852 returned self-administered mail questionnaires in 1962 or 1966 and in 1972 which queried for doctor-diagnosed myocardial infarction (MI), angina pectoris (AP) and HT. For each of 98 cases of fatal CHD, 78 cases of MI and 48 cases of AP, 4 controls were randomly selected. One control was selected for each of 319 HT cases. Significant negative associations between father''s occupational status and risk of combined fatal CHD and MI and between geographic mobility and risk of HT were noted in univariate analysis. These associations persisted with stratification by individual confounding factors and by a multivariate confounder-summarizing score. Intergenerational mobility, as indicated by occupational status of the father, was associated with a 1.5 .times. increased risk of fatal CHD and MI. Intragenerational geographic mobility was associated with a slightly reduced risk of HT.