Morphology of peripheral airways in current smokers and ex-smokers.
Morphology of peripheral airways in current smokers and ex-smokers.
复制标题
当前吸烟者和戒烟者的外周气道形态。
DOI：
--
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
J. Hogg
中科院分区：
文献类型：
--
作者：
J. Wright;L. Lawson;P. Paré;B. Wiggs;S. Kennedy;J. Hogg
为了调查吸烟状况对肺功能和周围气道病理变化的影响，我们研究了 97 名因硬币病变而接受开胸手术的患者。患者被分为 4 组：不吸烟者 (n = 9)、当前吸烟者 (n = 51) 以及手术前戒烟时间少于 (n = 18) 或超过 (n = 19) 2 年的患者。我们发现，与不吸烟者相比，当前吸烟者有气流阻塞和肺容量异常的证据。戒烟者的肺容量与不吸烟者相似，但显示出阻塞的证据，FEV1/FVC 值介于非吸烟者和当前吸烟者的值之间。小气道检查显示，与不吸烟者相比，当前吸烟者和戒烟者的膜状细支气管仅表现出杯状细胞化生增加；目前和戒烟者的呼吸细支气管显示管腔内和气道壁炎症细胞、壁纤维化和色素沉积增加。我们的结论是，目前吸烟的患者肺功能下降，这与气道结构异常有关。尽管那些已经戒烟的人的功能更接近于不吸烟的人群，但当前吸烟者和戒烟者之间的结构变化没有明显差异。
To investigate the effect of smoking status on pulmonary function and pathologic changes in the peripheral airways, we studied 97 patients who underwent thoracotomy for coin lesions. The patients were divided into 4 groups: nonsmokers (n = 9), current smokers (n = 51), and those who had ceased smoking for less than (n = 18) or more than (n = 19) 2 yr prior to surgery. We found that current smokers had evidence of air-flow obstruction with abnormal lung volumes when compared with nonsmokers. Ex-smokers had lung volumes similar to those of nonsmokers, but showed evidence of obstruction, with the FEV1/FVC between the values found for nonsmokers and current smokers. Examination of the small airways showed that the membranous bronchioles of current smokers and ex-smokers displayed only increased goblet cell metaplasia when compared with those in nonsmokers; the respiratory bronchioles of current and ex-smokers showed increases in intraluminal and airway wall inflammatory cells, wall fibrosis, and pigment deposition. We conclude that patients who currently smoke cigarettes have reduced lung function that is associated with abnormalities of airway structure. Although those who have stopped smoking have function that is closer to the nonsmoking group, there is no apparent difference in structural change between current and ex-smokers.