Identification of a cellular node for motor control pathways.
Identification of a cellular node for motor control pathways.
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DOI：
10.1038/nn.3675
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发表时间：
2014-04
影响因子：
25
通讯作者：
Pfaff SL
中科院分区：
文献类型：
--
作者：
Levine AJ;Hinckley CA;Hilde KL;Driscoll SP;Poon TH;Montgomery JM;Pfaff SL
动物丰富的行为指令在中枢神经系统中被编码为一组运动神经元激活模式，也称为“运动协同作用”。然而，人们对协调这些运动程序的神经元及其细胞特性和连接性知之甚少。在这里，我们在小鼠脊髓中鉴定了一群分子定义的运动协同编码器（MSE）神经元，它们可能代表随意和反射运动神经通路的中心节点。该群体接收来自运动皮层和感觉通路的直接输入，反过来，对脊髓运动神经元具有单突触输出。 MSE 神经元的光刺激驱动了多个运动组的可靠活动模式，我们发现诱发的运动模式根据受刺激的 MSE 的轴尾位置而变化。我们推测这些神经元组成了一个用于编码协调运动输出程序的细胞网络。
The rich behavioral repertoire of animals is encoded in the CNS as a set of motorneuron activation patterns, also called ‘motor synergies’. However, the neurons that orchestrate these motor programs as well as their cellular properties and connectivity are poorly understood. Here we identify a population of molecularly defined motor synergy encoder (MSE) neurons in the mouse spinal cord that may represent a central node in neural pathways for voluntary and reflexive movement. This population receives direct inputs from the motor cortex and sensory pathways and, in turn, has monosynaptic outputs to spinal motorneurons. Optical stimulation of MSE neurons drove reliable patterns of activity in multiple motor groups, and we found that the evoked motor patterns varied on the basis of the rostrocaudal location of the stimulated MSE. We speculate that these neurons comprise a cellular network for encoding coordinated motor output programs.