Tissue Tregs.
Tissue Tregs.
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DOI：
10.1146/annurev-immunol-032712-095948
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发表时间：
2016-05-20
影响因子：
29.7
通讯作者：
Mathis D
中科院分区：
文献类型：
--
作者：
Panduro M;Benoist C;Mathis D
免疫系统负责保护生物体免受其不断面对的无数微生物入侵者的侵害。越来越清楚的是，免疫系统还有第二个主要功能：维持机体的稳态。Foxp 3 + CD 4+调节性T细胞（TCRs）是这两种关键活性的重要贡献者，防御是TCRs通过淋巴器官循环的主要范围，并且主要由驻留在实质组织中的它们的对应物确保稳态。这篇综述主要集中在所谓的组织张力。我们首先调查现有的信息表型，功能，维持因素，和人类等效的三个最好的特点组织-Treg人群-那些在内脏脂肪组织，骨骼肌，结肠固有层。然后，我们试图从这一机构的工作，作为关注的起源，当地的适应，分子的支持，和目标的行动组织THEORY，特别是一般原则。
The immune system is responsible for defending an organism against the myriad of microbial invaders it constantly confronts. It has become increasingly clear that the immune system has a second major function: the maintenance of organismal homeostasis. Foxp3+CD4+ regulatory T cells (Tregs) are important contributors to both of these critical activities, defense being the primary purview of Tregs circulating through lymphoid organs, and homeostasis ensured mainly by their counterparts residing in parenchymal tissues. This review focuses on so-called tissue Tregs. We first survey existing information on the phenotype, function, sustaining factors, and human equivalents of the three best-characterized tissue-Treg populations—those operating in visceral adipose tissue, skeletal muscle, and the colonic lamina propria. We then attempt to distill general principles from this body of work—as concerns the provenance, local adaptation, molecular sustenance, and targets of action of tissue Tregs, in particular.