Early loss of dopamlinergic terminals in striosomes after MDMA administration to mice
Early loss of dopamlinergic terminals in striosomes after MDMA administration to mice
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DOI：
10.1002/syn.20466
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发表时间：
2008-01-01
期刊：
影响因子：
2.3
通讯作者：
Moratalla, Rosario
中科院分区：
文献类型：
--
作者：
Granado, Noelia;Escobedo, Isabel;Moratalla, Rosario
安非他明类似物 3,4-亚甲二氧基甲基安非他明（MDMA 或“摇头丸”）是一种流行的滥用药物，与大鼠相比，它对小鼠产生不同的神经毒性作用。在小鼠中，摇头丸会对纹状体多巴胺末端造成损害，对含有血清素 (5-HT) 的神经元几乎没有长期影响。纹状体的一个相关特征是其纹状体/基质区室组织；由不同的连接和功能定义。在这项研究中，我们检测了 MDMA 对小鼠纹状体纹状体和基质区室中酪氨酸羟化酶 (TH) 和多巴胺转运蛋白 (DAT) 免疫反应性的长期影响。与对照动物相比，给予 MDMA 的小鼠纹状体中 TH 和 DAT 免疫染色显着减少。有趣的是，这种效应在纹状体中比在基质中更为明显。这些数据提供了第一个证据，表明小鼠纹状体的纹状体和基质区室对 MDMA 具有不同的脆弱性，并且 MDMA 在小鼠中引起的长期神经毒性主要与纹状体多巴胺纤维的损失有关。
The amphetamine analogue 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy") is a popular drug of abuse which causes different neurotoxic effects in the mouse compared with the rat. In mice, MDMA produces damage to striatal dopamine terminals, having little long-term effects on serotonin (5-HT) containing neurons. A relevant feature of the striatum is its striosome/matrix compartmental organization; defined by different connexions, and functions. In this study we examined the long-term effect induced by MDMA on tyrosine hydroxylase (TH) and dopamine transporter (DAT) immunoreactivity in the striosomes and matrix compartments of mouse striatum. Mice given MDMA showed significant reductions in TH and DAT immunostaining in striatum compared with control animals. Interestingly, this effect was considerably more pronounced in striosomes than in the matrix. These data provide the first evidence that striosomes and matrix compartments of the mouse striatum have differential vulnerability to MDMA and that the long-term neurotoxicity induced by MDMA in mice is primarily associated with a loss of striosomal dopamine fibres.