Subthalamic nucleus activity dissociates proactive and reactive inhibition in patients with Parkinson's disease
Subthalamic nucleus activity dissociates proactive and reactive inhibition in patients with Parkinson's disease
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DOI：
10.1016/j.neuroimage.2013.10.070
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发表时间：
2014-05-01
期刊：
影响因子：
5.7
通讯作者：
Bastin, Julien
中科院分区：
文献类型：
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作者：
Benis, Damien;David, Olivier;Bastin, Julien
行动选择模型假定丘脑底核（subthalamic nucleus，简称丘脑底核）的关键参与，特别是在反应性抑制过程中，对突然刺激的不适当反应必须被推翻。当受试者准备潜在地抑制他们的行为时，前摄抑制也可以发挥关键作用。在这里，我们假设SIN反应和主动抑制控制可能是由不同的潜在机制与特定的时间配置文件。在12名帕金森病患者中，在修改的停止信号任务（SST）期间的直接神经记录显示，在较小幅度和较短持续时间的反应性抑制期间，比在运动执行期间，β带活动（β A，13-35 Hz）减少。至关重要的是，β A相对增加的起始潜伏期发生在停止信号反应时间之前。因此，它可以被认为是一个“停止”信号，抑制了支持运动执行的丘脑-皮层活动。最后，结果还揭示了在前摄抑制期间，脑皮层中的β A水平较高，这与患者的抑制表现相关。我们建议，β-A在大脑皮层中将参与实现一个“抓住你的马”信号，以延迟运动反应，从而优先考虑的准确性相比，速度。简而言之，我们的研究结果提供了强有力的电生理学支持的假设作用，在执行控制潜在的主动和反应性反应抑制的大脑皮层。(C)2013 Elsevier Inc. All rights reserved.
Models of action selection postulate the critical involvement of the subthalamic nucleus (STN), especially in reactive inhibition processes when inappropriate responses to a sudden stimulus must be overridden. The STN could also play a key role during proactive inhibition, when subjects prepare to potentially suppress their actions. Here, we hypothesized that SIN responses to reactive and proactive inhibitory control might be driven by different underlying mechanisms with specific temporal profiles. Direct neural recordings in twelve Parkinson's disease patients during a modified stop signal task (SST) revealed a decrease of beta band activity (beta A, 13-35 Hz) in the STN during reactive inhibition of smaller amplitude and shorter duration than during motor execution. Crucially, the onset latency of this relative increase of beta A took place before the stop signal reaction time. It could thus be thought of as a "stop" signal inhibiting thalamo-cortical activity that would have supported motor execution. Finally, results also revealed a higher level of beta A in the STN during proactive inhibition, which correlated with patient's inhibitory performances. We propose that beta A in the STN would here participate in the implementation of a "hold your horse" signal to delay motor responses, thus prioritizing accuracy as compared to speed. In brief, our results provide strong electrophysiological support for the hypothesized role of the STN during executive control underlying proactive and reactive response suppression. (C) 2013 Elsevier Inc. All rights reserved.