Wear resistance of artificial hip joints with poly(2-methacryloyloxyethyl phosphorylcholine) grafted polyethylene: Comparisons with the effect of polyethylene cross-linking and ceramic femoral heads
Wear resistance of artificial hip joints with poly(2-methacryloyloxyethyl phosphorylcholine) grafted polyethylene: Comparisons with the effect of polyethylene cross-linking and ceramic femoral heads
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DOI：
10.1016/j.biomaterials.2009.02.020
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发表时间：
2009-06-01
期刊：
影响因子：
14
通讯作者：
Takatori, Yoshio
中科院分区：
文献类型：
--
作者：
Moro, Toru;Kawaguchi, Hiroshi;Takatori, Yoshio
聚乙烯（PE）内衬的磨损颗粒导致人工髋关节无菌性松动仍然是限制其使用寿命的破坏性问题。我们在此报告称，在PE内衬表面接枝聚合物聚（2-甲基丙烯酰氧基乙基磷酰胆碱（MPC））（PMPC）可显著降低髋关节模拟器条件下的磨损。研究了交联聚乙烯材料和改变材料的股骨头材料对聚乙烯材料磨损性能的影响。无论PE内衬的交联或股骨头材料的差异如何，内衬上的PMPC移植物增加了亲水性并降低了摩擦扭矩。在髋关节模拟器实验期间（5 x 10（6）个负载循环），交联导致磨损量减少和颗粒尺寸减小，而股骨头材料对其没有影响。PMPC移植消除了磨损产生，通过内衬表面几乎没有磨损证实，与内衬交联或股骨头材料无关。结论：聚乙烯内衬上植入聚碳酸酯对延长人工髋关节寿命的效果优于内衬交联或更换股骨头材料。(C)2009爱思唯尔有限公司保留所有权利。
Aseptic loosening of artificial hip joints induced by wear particles from the polyethylene (PE) liner remains the ruinous problem limiting their longevity. We reported here that grafting with a polymer, poly(2-methacryloyloxyethyl phosphorylcholine (MPC)) (PMPC) on the PE liner surface dramatically decreased the wear production under a hip joint simulator condition. We examined that the effect of properties of both PE by cross-linking and femoral head by changing the materials on wearing properties of PE. The PMPC grafting on the liners increased hydrophilicity and decreased friction torque, regardless of the cross-linking of the PE liner or the difference in the femoral head materials. During the hip joint simulator experiments (5 x 10(6) cycles of loading), cross-linking caused a decrease of wear amount and a reduction of the particle size, while the femoral head materials did not affect it. The PMPC grafting abrogated the wear production, confirmed by almost no wear of the liner surface, independently of the liner cross-linking or the femoral head material. We concluded that the PMPC grafting on the PE liner surpasses the liner cross-linking or the change of femoral head materials for extending longevity of artificial hip joints. (C) 2009 Elsevier Ltd. All rights reserved.