Oxytocin Protects Hippocampal Memory and Plasticity from Uncontrollable Stress.
Oxytocin Protects Hippocampal Memory and Plasticity from Uncontrollable Stress.
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DOI：
10.1038/srep18540
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发表时间：
2015-12-21
影响因子：
4.6
通讯作者：
Han JS
中科院分区：
文献类型：
--
作者：
Lee SY;Park SH;Chung C;Kim JJ;Choi SY;Han JS
海马体很容易受到无法控制的压力的影响，并且富含催产素受体，但它们对海马体功能的相互作用影响尚不清楚。本研究旨在确定鼻内催产素给药对雄性大鼠应激诱导的突触可塑性和空间记忆变化的影响。虽然给予赋形剂的应激大鼠表现出长时程增强受损、长期抑郁增强和空间记忆减弱，但在给予催产素的应激大鼠中没有观察到这些变化。为了揭示介导这些效应的潜在信号机制，我们检查了海马中磷酸化细胞外信号调节激酶（pERK）的水平。蛋白质印迹显示催产素治疗可阻断应激诱导的 pERK 改变。此外，催产素受体拮抗剂 L-368,899 抑制催产素对海马应激记忆的保护作用。因此，鼻内给予催产素通过作用于催产素受体并调节 ERK 活性，减少了对大鼠海马突触可塑性和记忆力的应激影响。这项研究表明，外源性催产素可能是对抗压力对神经认知的有害影响的有效治疗手段。
The hippocampus is vulnerable to uncontrollable stress and is enriched with oxytocin receptors, but their interactive influences on hippocampal functioning are unknown. This study aimed to determine the effects of intranasal oxytocin administration on stress-induced alterations in synaptic plasticity and spatial memory in male rats. While vehicle-administered stressed rats showed impairment in long-term potentiation, enhancement in long-term depression, and weakened spatial memory, these changes were not observed in oxytocin-administered stressed rats. To reveal the potential signaling mechanism mediating these effects, levels of phosphorylated extracellular signal-regulated kinases (pERK) in the hippocampus was examined. Western blotting showed that oxytocin treatment blocked stress-induced alterations of pERK. Additionally, the oxytocin receptor antagonist L-368,899 inhibited the oxytocin’s protective effects on hippocampal memory to stress. Thus, intranasal administration of oxytocin reduced stress effects on hippocampal synaptic plasticity and memory in rats via acting on oxytocin receptors and regulating ERK activity. This study suggests that exogenous oxytocin may be a therapeutically effective means to counter the detrimental neurocognitive effects of stress.