Normal values of aortic dimensions, distensibility, and pulse wave velocity in children and young adults: a cross-sectional study.
Normal values of aortic dimensions, distensibility, and pulse wave velocity in children and young adults: a cross-sectional study.
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DOI：
10.1186/1532-429x-14-77
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发表时间：
2012-11-14
期刊：
影响因子：
--
通讯作者：
Rickers C
中科院分区：
文献类型：
--
作者：
Voges I;Jerosch-Herold M;Hedderich J;Pardun E;Hart C;Gabbert DD;Hansen JH;Petko C;Kramer HH;Rickers C
主动脉增大和生物弹性受损在一些心脏和非心脏疾病中是有意义的，因为它们可以导致心血管并发症。心血管磁共振(CMR)作为一种无创性的心血管评估工具越来越为人们所接受。CMR评价主动脉解剖和生物弹性，即主动脉扩张性和脉搏波速度(PWV)，准确、重复性好，有助于识别主动脉解剖和生物弹性异常。然而，健康儿童和年轻人的正常CMR值是缺乏的。采用3.0Tesla CMR扫描仪对71例心脏健康受试者(年龄16.4±7.6岁，范围2.3~28.3岁)进行了检查。测量升主动脉和降主动脉四个部位的主动脉横截面积和扩张性。通过测量升主动脉和降主动脉近端之间的主动脉段的血流速度来评估PWV。用Lambda-Mu-Sigma(LMS)方法获得主动脉横截面积、主动脉扩张性和PWV随年龄变化的百分位数曲线。与身高、体重、体表面积和年龄相关的主动脉面积、脉压和主动脉扩张性(主动脉横截面积：r = 0.8~0.9，p <； 0.001；pwv：r = 0.2 5~0.32，p = 0.047~0.009；主动脉扩张性r = -0.43~-0.62，p <； 0.001)。性别差异不显著。这项研究提供了3岁至29岁儿童和青少年胸主动脉横截面积、扩张性和脉搏波速度的百分位数曲线。这些数据可为检测心血管疾病患者的主动脉病变提供参考。
Aortic enlargement and impaired bioelasticity are of interest in several cardiac and non-cardiac diseases as they can lead to cardiovascular complications. Cardiovascular magnetic resonance (CMR) is increasingly accepted as a noninvasive tool in cardiovascular evaluation. Assessment of aortic anatomy and bioelasticity, namely aortic distensibility and pulse wave velocity (PWV), by CMR is accurate and reproducible and could help to identify anatomical and bioelastic abnormalities of the aorta. However, normal CMR values for healthy children and young adults are lacking. Seventy-one heart-healthy subjects (age 16.4 ± 7.6 years, range 2.3 - 28.3 years) were examined using a 3.0 Tesla CMR scanner. Aortic cross-sectional areas and aortic distensibility were measured at four positions of the ascending and descending thoracic aorta. PWV was assessed from aortic blood flow velocity measurements in a aortic segment between the ascending aorta and the proximal descending aorta. The Lambda-Mu-Sigma (LMS) method was used to obtain percentile curves for aortic cross-sectional areas, aortic distensibility and PWV according to age. Aortic areas, PWV and aortic distensibility (aortic cross-sectional areas: r = 0.8 to 0.9, p < 0.001; PWV: r = 0.25 to 0.32, p = 0.047 to 0.009; aortic distensibility r = -0.43 to -0.62, p < 0.001) correlated with height, weight, body surface area, and age. There were no significant sex differences. This study provides percentile curves for cross-sectional areas, distensibility and pulse wave velocity of the thoracic aorta in children and young adolescents between their 3rd and 29th year of life. These data may serve as a reference for the detection of pathological changes of the aorta in cardiovascular disease.