Effects of disclosing financial interests on attitudes toward clinical research.
Effects of disclosing financial interests on attitudes toward clinical research.
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披露经济利益对临床研究态度的影响。
DOI：
10.1007/s11606-008-0590-4
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发表时间：
2008
影响因子：
5.7
通讯作者：
Sugarman,Jeremy
中科院分区：
文献类型：
--
作者：
Weinfurt,KevinP;Hall,MarkA;Dinan,MichaelaA;DePuy,Venita;Friedman,JoëlleY;Allsbrook,JenniferS;Sugarman,Jeremy
BackgroundThe effects of disclosing financial interests to potential research participants are not well understood.ObjectiveTo examination the effects of financial interest disclosures on potential research participants' attitudes toward clinical research.Design and problematic experiment在美国进行了一项计算机化的实验，有3，623名糖尿病或哮喘的成年人，按严重程度分组。受访者阅读了与他们的诊断相关的假设临床试验的描述，其中包括财务披露声明。受访者收到了5份披露声明中的1份。测量参与假设临床试验的意愿，有关经济利益的信息的相对重要性，阅读披露声明后信任的变化，关于经济利益的惊讶，结果参与假设性临床试验的意愿在不同的受试者中没有显著差异，财务披露的类型。受访者认为，在决定参与时，披露的信息不如其他因素重要。信息披露与一些受访者对研究人员的信任程度降低有关，尽管一些受访者的信任程度有所增加。大多数受访者对经济利益并不感到惊讶。拥有股权的研究人员被认为是更麻烦的研究人员谁是通过人均payment.ConclusionsAside研究人员持有股权的研究成本补偿，披露给潜在的研究参与者的金融利益的研究，建议在最近的政策，是不太可能影响愿意参与研究。
BackgroundThe effects of disclosing financial interests to potential research participants are not well understood.ObjectiveTo examine the effects of financial interest disclosures on potential research participants’ attitudes toward clinical research.Design and ParticipantsComputerized experiment conducted with 3,623 adults in the United States with either diabetes mellitus or asthma, grouped by lesser and greater severity. Respondents read a description of a hypothetical clinical trial relevant to their diagnosis that included a financial disclosure statement. Respondents received 1 of 5 disclosure statements.MeasurementsWillingness to participate in the hypothetical clinical trial, relative importance of information about the financial interest, change in trust after reading the disclosure statement, surprise regarding the financial interest, and perceived effect of the financial interest on the quality of the clinical trial.ResultsWillingness to participate in the hypothetical clinical trial did not differ substantially among the types of financial disclosures. Respondents viewed the disclosed information as less important than other factors in deciding to participate. Disclosures were associated with some respondents trusting the researchers less, although trust among some respondents increased. Most respondents were not surprised to learn of financial interests. Researchers owning equity were viewed as more troubling than researchers who were compensated for the costs of research through per capita payments.ConclusionsAside from a researcher holding an equity interest, the disclosure to potential research participants of financial interests in research, as recommended in recent policies, is unlikely to affect willingness to participate in research.