ANTIBODY-RESPONSE TO PNEUMOCOCCAL VACCINATION IN CHILDREN YOUNGER THAN 5-YEARS OF AGE
ANTIBODY-RESPONSE TO PNEUMOCOCCAL VACCINATION IN CHILDREN YOUNGER THAN 5-YEARS OF AGE
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DOI：
10.1093/infdis/148.1.131
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发表时间：
1983-01-01
影响因子：
6.4
通讯作者：
HANSMAN, DJ
中科院分区：
文献类型：
--
作者：
DOUGLAS, RM;PATON, JC;HANSMAN, DJ
Sera were analyzed by radioimmunoassay for type-specific pneumococcal antibody in 249 children aged 6-54 mo., who were participating in a controlled trial of a 14-valent pneumococcal vaccine. Levels of serum antibody to all serotypes increased after immunization in all age groups tested. For all serotypes, the antibody response increased progressively with age whether response was viewed as antibody doubling, relative increase in geometric mean or final antibody level. Responses were poor up to the age of 5 yr for the important pediatric serotypes 6A, 14, 19F and 23F. Seventeen children under the age of 2 yr at the time of primary immunization received booster doses of vaccine 6 mo. later. There was no significant increase in antibody to any serotype; the geometric mean antibody levels fell for most types. Immune response to the pediatric serotypes was poor until the age of 4.5 yr.
