Cardiac expression of placental growth factor predicts the improvement of chronic phase left ventricular function in patients with acute myocardial infarction
Cardiac expression of placental growth factor predicts the improvement of chronic phase left ventricular function in patients with acute myocardial infarction
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DOI：
10.1016/j.jacc.2005.11.064
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发表时间：
2006-04-18
影响因子：
24
通讯作者：
Salto, Y
中科院分区：
文献类型：
--
作者：
Iwama, H;Uemura, S;Salto, Y
我们的目的是研究胎盘生长因子（PlGF）在急性心肌梗死（AMI）患者心脏中的表达及其临床意义。背景胎盘生长因子已知通过激活单核细胞和诱导血管生成来刺激伤口愈合。PIGF在AMI中的临床意义尚不清楚。在AMI后第1、3、7天采集外周血。在急性冠状动脉再通之前和之后，还从冠状动脉（CAos）和冠状窦（CS）中采集血液。结果急性心肌梗死患者第3天外周血PIGF水平明显高于对照组，第4天PIGF水平明显高于对照组，第5天PIGF水平明显高于对照组，第6天PIGF水平明显高于对照组。再通后的血浆PIGF水平在CS中显著高于CAos，这表明心脏产生和释放PIGF。第3天外周血浆PIGF水平与急性期左心室射血分数（LVEF）呈负相关，与急性期外周单核细胞峰值计数和慢性期左心室射血分数变化呈正相关。胎盘生长因子信使核糖核酸的表达是26.6倍以上的小鼠AMI模型比在shamoperated小鼠，和PlGF主要表达在梗死region.Conclusions的内皮细胞中的梗死心肌，尤其是内皮细胞在心肌梗死急性期胎盘生长因子是迅速产生。胎盘生长因子可能过度表达以补偿急性缺血性损伤，并且似乎随后在慢性期起改善LVEF的作用。
OBJECTIVES Our aim was to investigate cardiac expression of placental growth factor (PIGF) and its clinical significance in patients with acute myocardial infarction (AMI).BACKGROUND Placental growth factor is known to stimulate wound healing by activating mononuclear cells and inducing angiogenesis. The clinical significance of PIGF in AMI is not yet known.METHODS Fifty-five AMI patients and 43 control subjects participated in the study. Peripheral blood sampling was performed on days 1, 3, and 7 after AMI. Blood was also sampled from the coronary artery (CAos) and the coronary sinus (CS), before and after acute coronary recanalization. Cardiac expression of PIGF was analyzed in a mouse AMI model.RESULTS In AMI patients, peripheral plasma PIGF levels on day 3 were significantly higher than in control subjects. Plasma PIGF levels just after recanalization were significantly higher in the CS than the CAos, which indicates cardiac production and release of PIGF. Peripheral plasma levels of PIGF on day 3 were negatively correlated with the acute phase left ventricular ejection fraction (LVEF), positively correlated with both acute phase peak peripheral monocyte counts and chronic phase changes in LVEF. Placental growth factor messenger ribonucleic acid expression was 26.6-fold greater in a mouse AMI model than in shamoperated mice, and PlGF was expressed mainly in endothelial cells within the infarct region.CONCLUSIONS Placental growth factor is rapidly produced in infarct myocardium, especially by endothelial cells during the acute phase of myocardial infarction. Placental growth factor might be over-expressed to compensate the acute ischemic damage, and appears to then act to improve LVEF during the chronic phase.