Modeling the current distribution during transcranial direct current stimulation
Modeling the current distribution during transcranial direct current stimulation
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DOI：
10.1016/j.clinph.2006.04.009
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发表时间：
2006-07-01
影响因子：
4.7
通讯作者：
Hallett, Mark
中科院分区：
文献类型：
--
作者：
Miranda, Pedro Cavaleiro;Lomarev, Mikhail;Hallett, Mark
目的：目的：研究经颅直流电刺激（tDCS）过程中人体头部电流密度的大小和方向的空间分布，方法：采用数值方法计算头部电流密度的空间分布。该模型被定位在'MNI空间'，以方便空间coordination.Results的解释：电流密度矢量的大小和方向说明在选定的脑切片四个不同的电极蒙太奇。在tDCS期间注入的电流的大约一半通过头皮分流，这取决于电极尺寸和位置。使用2.0 mA的刺激电流，大脑相关区域的电流密度大小为0.1 A/m（2），对应于0.22 V/m的电场。基于头部球形模型的计算可以提供关于tDCS期间大脑中电流密度矢量的大小和方向的有用信息，考虑到电极的几何形状和位置。尽管固有的局限性的球形头模型，计算值是在最近的体外研究中使用的调制的神经元activity.Significance：本文提出的方法可用于评估电流分布在tDCS使用新的电极蒙太奇，以帮助优化蒙太奇，针对特定区域的大脑或初步调查遵守安全指南。(c)2006年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To investigate the spatial distribution of the magnitude and direction of the current density in the human head during transcranial direct current stimulation (tDCS).Methods: The current density distribution was calculated using a numerical method to implement a standard spherical head model into which current was injected by means of large electrodes. The model was positioned in 'MNI space' to facilitate the interpretation of spatial coordinates.Results: The magnitude and direction of the current density vector are illustrated in selected brain slices for four different electrode montages. Approximately half of the current injected during tDCS is shunted through the scalp, depending on electrode dimension and position. Using stimulating currents of 2.0 mA, the magnitude of the current density in relevant regions of the brain is of the order of 0.1 A/m(2), corresponding to an electric field of 0.22 V/m.Conclusions: Calculations based on a spherical model of the head can provide useful information about the magnitude and direction of the current density vector in the brain during tDCS, taking into account the geometry and position of the electrodes. Despite the inherent limitations of the spherical head model, the calculated values are comparable to those used in the most recent in vitro studies on modulation of neuronal activity.Significance: The methodology presented in this paper may be used to assess the current distribution during tDCS using new electrode montages, to help optimize montages that target a specific region of the brain or to preliminarily investigate compliance with safety guidelines. (c) 2006 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.