Meta-analysis: randomized controlled trials of 4-L polyethylene glycol and sodium phosphate solution as bowel preparation for colonoscopy.
Meta-analysis: randomized controlled trials of 4-L polyethylene glycol and sodium phosphate solution as bowel preparation for colonoscopy.
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DOI：
10.1111/j.1365-2036.2010.04326.x
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发表时间：
2010-07
影响因子：
7.6
通讯作者：
Imperiale TF
中科院分区：
文献类型：
--
作者：
Juluri R;Eckert G;Imperiale TF
比较PEG和NaP的随机对照试验（RCTs）不一致。比较PEG和NaP在肠道准备中的疗效和耐受性。我们使用MEDLINE和EMBASE来识别1990年至2008年间发表的英文随机对照试验，比较4升PEG和两个45毫升NaP在成人择期结肠镜检查中的作用。我们计算了准备质量和完成准备的受试者比例的合并优势比（ORs）。从18项试验（n=2792）中，接受NaP的受试者比接受PEG的受试者更有可能获得优秀或良好质量的准备（82%对77%；or =1.43; 95% CI, 1.01-2.00）。在更详细地报告了准备质量的10个试验亚组中，准备质量优良、良好、一般或差的比例没有差异。在评估制剂完成率的9项试验中，接受NaP的患者比接受4-L PEG的患者更有可能完成制剂（分别为3.9%对9.8%，未完成制剂；OR= 0.40； CI, 0.17-0.88）。在18个NaP与4 L PEG的头对头随机对照试验中，NaP更有可能完成，并产生优质或良好的准备。
Randomized controlled trials (RCTs) comparing PEG vs. NaP are inconsistent. Compare the efficacy of and tolerance to PEG vs. NaP for bowel preparation. We used MEDLINE and EMBASE to identify English-language RCTs published between 1990 and 2008 comparing 4 L PEG with two 45 ml doses of NaP in adults undergoing elective colonoscopy. We calculated the pooled odds ratios (ORs) for preparation quality and proportion of subjects completing the preparation. From 18 trials (n=2792), subjects receiving NaP were more likely to have an excellent or good quality preparation than those receiving PEG (82% vs. 77%; OR=1.43; 95% CI, 1.01-2.00). Among a subgroup of 10 trials in which prep quality was reported in greater detail, there were no differences in the proportions of excellent, good, fair or poor preparation quality. Among nine trials that assessed preparation completion rates, patients receiving NaP were more likely to complete the preparation than patients receiving 4-L PEG (3.9% vs. 9.8%, respectively, did not complete the preparation; OR= 0.40; CI, 0.17-0.88). Among 18 head-to-head RCTs of NaP vs. 4 L PEG, NaP was more likely to be completed and to result in an excellent or good quality preparation.