Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment
Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment
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DOI：
10.1016/j.biomaterials.2012.11.048
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发表时间：
2013-03-01
期刊：
影响因子：
14
通讯作者：
Yeh, Chih-Kuang
中科院分区：
文献类型：
--
作者：
Fan, Ching-Hsiang;Ting, Chien-Yu;Yeh, Chih-Kuang
目前的化疗剂不仅杀死肿瘤细胞，而且诱导全身毒性，这显著限制了它们的剂量。在微泡（MB）存在下的聚焦超声（FUS）能够瞬时和局部打开血脑屏障（BBB），从而增强化疗药物递送到脑实质中用于胶质瘤治疗。我们先前的结果证明了将药物（1，3-双（2-氯乙基）-1-亚硝基脲，BCNU）负载的MB与FUS诱导的BBB开放结合使用以改善局部药物递送并降低全身毒性的成功。在这里，我们介绍了新的VEGF靶向，载药MB，显着进一步提高靶向药物释放和减少肿瘤的进展，在大鼠模型中，使用FUS-BBB开放策略。这项研究提出了一个有前途的方向，为未来的MB设计，旨在针对脑肿瘤治疗，和未来可能的扩展MB的应用程序对治疗不确定性使用。(C)2012爱思唯尔有限公司保留所有权利。
Current chemotherapeutic agents do not only kill tumor cells but also induce systemic toxicity that significantly limits their dosage. Focused ultrasound (FUS) in the presence of microbubbles (MBs) is capable of transient and local opening of the blood brain barrier (BBB) that enhances chemotherapeutic drug delivery into the brain parenchyma for glioma treatment. Our previous results demonstrated the success of combining the use of drug (1,3-bis(2-chloroethyl)-1-nitrosourea, BCNU)-loaded MBs with FUS-induced BBB opening to improve local drug delivery and reduce systemic toxicity. Here we introduce novel VEGF-targeting, drug-loaded MBs that significantly further enhance targeted drug release and reduce tumor progression in a rat model, using the FUS-BBB opening strategy. This study suggests a promising direction for future MB design aimed at targeted brain tumor therapy, and the possible future extension of MB application towards theragnostic use. (C) 2012 Elsevier Ltd. All rights reserved.