Low maternal 25-hydroxyvitamin D concentration increases the risk of severe and mild preeclampsia.
Low maternal 25-hydroxyvitamin D concentration increases the risk of severe and mild preeclampsia.
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DOI：
10.1016/j.annepidem.2016.09.015
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发表时间：
2016-12
影响因子：
5.6
通讯作者：
Bodnar LM
中科院分区：
文献类型：
--
作者：
Baca KM;Simhan HN;Platt RW;Bodnar LM
The objective of this case-cohort study was to evaluate the relationship between maternal 25-hydroxyvitamin D (25(OH)D) concentration and preeclampsia overall and by severity. From an eligible cohort of 12,861 women who had serum banked from aneuploidy screening in Pittsburgh, Pennsylvania from 1999 to 2010, we randomly sampled a subcohort of 2327 pregnancies and all remaining preeclampsia cases (n = 650 cases). Preeclampsia (defined as new-onset hypertension and proteinuria) and its mild and severe forms were identified using ICD-9 codes. Maternal serum collected at 20 weeks or less gestation was measured for 25(OH)D. We used log-binomial regression with restricted cubic splines to estimate the association between 25(OH)D and preeclampsia after adjusting for confounders. Approximately 21% of the randomly selected sample had 25(OH)D less than 50 nmol per L. We found that the adjusted risk of preeclampsia declined as serum 25(OH)D increased to 50 nmol per L and then plateaued (test of nonlinearity P < .05). The adjusted preeclampsia risk ratios (95% confidence intervals) for 25(OH)D less than 25 nmol per L, 25 to 49.9 nmol per L, and 50 to 74.9 nmol per L were 2.4 (1.2–4.8), 1.1 (0.69–1.7), and 1.3 (0.89–1.8), respectively, compared with those with 25(OH)D 75 nmol per L and over. Similar associations were observed with severe and mild preeclampsia. Vitamin D deficiency increases risks of severe and mild forms of preeclampsia.
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影响因子：
7.2
作者：
Bodnar LM;Platt RW;Simhan HN
通讯作者：
Simhan HN
DOI：
10.1136/bmj.f6564
发表时间：
2013-11-07
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Ananth CV;Keyes KM;Wapner RJ
通讯作者：
Wapner RJ
影响因子：
105.7
作者：
Aghajafari, Fariba;Nagulesapillai, Tharsiya;Rabi, Doreen M.
通讯作者：
Rabi, Doreen M.
胎儿期和围产期氧化应激介导的衰老。
影响因子：
--
作者：
Marseglia L;D'Angelo G;Manti S;Arrigo T;Barberi I;Reiter RJ;Gitto E
通讯作者：
Gitto E
影响因子：
3.7
作者：
Brodowski L;Burlakov J;Myerski AC;von Kaisenberg CS;Grundmann M;Hubel CA;von Versen-Höynck F
通讯作者：
von Versen-Höynck F