Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands
Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands
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DOI：
10.1039/d0cc00247j
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发表时间：
2020-05-14
影响因子：
4.9
通讯作者：
Stocker, Bridget L.
中科院分区：
文献类型：
--
作者：
Braganza, Chriselle D.;Motozono, Chihiro;Stocker, Bridget L.
mucal -associated invariant T （MAIT）是先天样T细胞的一个子集，可被MR1呈递的尿嘧啶配体激活。我们首次证明尿嘧啶激动剂5-OP-RU的6-氨基烷基链的变化可以决定MAIT细胞的激动或拮抗活性。因此，一种具有类似于5-OP-RU功能的简化激动剂和一种具有类似于已知MAIT细胞拮抗剂Ac-6-FP活性的新结构拮抗剂被鉴定出来。
Mucosal-associated invariant T (MAIT) are a subset of innate-like T cells that are activated by uracil ligands presented by MR1. For the first time, we demonstrate that changes to the 6-aminoalkyl chain on uracil agonist 5-OP-RU can determine agonistic or antagonistic MAIT cell activity. Insomuch, a simplified agonist with a functional profile similar to 5-OP-RU, and a new structural class of antagonist that exhibits similar activity to known MAIT cell antagonist Ac-6-FP, were identified.