Pentobarbital and halothane hyperpolarize cat α-motoneurons
Pentobarbital and halothane hyperpolarize cat α-motoneurons
复制标题
戊巴比妥和氟烷使猫 α 运动神经元超极化
DOI：
10.1016/0006-8993(86)90714-6
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发表时间：
1986
期刊：
影响因子：
2.9
通讯作者：
L. Glenn
中科院分区：
文献类型：
--
作者：
J. F. Whitney;L. Glenn
在连续用氟烷或戊巴比妥麻醉的清醒完整猫中研究了麻醉剂对脊髓 α 运动神经元膜电位的影响。戊巴比妥 (35 mg/kg) 和氟烷 (5%) 均诱导 5 mV 超极化和运动神经元自发突触活动减少。我们建议（1）单一 EPSP 频率的降低有助于超极化，（2）清醒完整制剂中可接受的运动神经元刺穿的膜电位标准应比麻醉制剂中去极化多 5 mV。
The effect of anesthetics on the membrane potential of spinal α-motoneurons was studied in awake-intact cats that were sequentially anesthetized with either halothane or pentobarbital. Pentobarbital (35 mg/kg) and halothane (5%) both induced a 5 mV hyperpolarization and a reduction in spontaneous synaptic activity of motoneurons. We suggest that (1) a reduction in the unitary EPSP frequencies contributes to the hyperpolarization and (2) the membrane potential criterion of acceptable impalements of motoneurons in awake-intact preparations should be 5 mV more depolarized than that in anesthetized preparations.