Gait characteristics of children with Williams syndrome with impaired visuospatial recognition: a three-dimensional gait analysis study
Gait characteristics of children with Williams syndrome with impaired visuospatial recognition: a three-dimensional gait analysis study
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DOI：
10.1007/s00221-020-05946-0
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发表时间：
2020-10-14
影响因子：
2
通讯作者：
Nakamura, Miho
中科院分区：
文献类型：
--
作者：
Ito, Yuji;Ito, Tadashi;Nakamura, Miho
威廉姆斯综合征（WS）是一种以智力障碍和视觉空间识别障碍为特征的遗传性神经发育障碍。本研究的目的是用三维步态分析（3DGA）来分析WS儿童视觉空间识别受损的步态特征，以阐明步态适应需要补偿it.3DGA进行了8 WS儿童视觉空间识别受损（平均年龄，11.8岁）和9年龄，性别，身高和体重匹配的控制。比较两组的临床数据、基本运动测试和在平坦表面上行走和在垫子上行走时的步态变量，并分析WS儿童中变量之间的相关性。WS儿童平衡功能受损，但无肌无力。在平坦表面上行走时，WS组表现出步行速度减慢、步长短、步长变异性增加、整个站立阶段膝关节屈曲增加、水平骨盆运动范围（ROM）增加、步态偏差指数低和步态轮廓评分高，这些都是步态质量的指标。在走上垫子时，WS组的行走速度进一步降低，摆动阶段的矢状髋关节屈曲和踝关节背屈ROM减少。平衡功能受损与摆动阶段步长变异性增加和踝关节矢状背屈ROM减少显著相关。详细的步态模式的WS儿童的视觉空间识别障碍。这些发现表明，受损的视觉空间识别和平衡功能有助于步态适应。
Williams syndrome (WS) is a genetically based neurodevelopmental disorder characterized by intellectual disability and impaired visuospatial recognition. The aim of this study was to analyze the gait characteristics of WS children with impaired visuospatial recognition using a three-dimensional gait analysis (3DGA) to clarify the gait adaptation needed to compensate for it. 3DGA was performed in 8 WS children with impaired visuospatial recognition (mean age, 11.8 years) and 9 age-, sex-, height-, and weight-matched controls. Clinical data, fundamental motor tests, and gait variables while walking on a flat surface and walking up a mat were compared between the two groups, and the correlations between variables were analyzed in the WS children. WS children showed impairment of balance function without muscle weakness. In walking on a flat surface, the WS group showed reduced walking speed, short step length, increased variability of step length, increased knee flexion throughout the stance phase, increased horizontal pelvic range of motion (ROM), and a low Gait Deviation Index and a high Gait Profile Score, which are indices of gait quality. In walking up a mat, the WS group showed further reduced walking speed and decreased sagittal hip flexion and ankle dorsiflexion ROM in the swing phase. Impaired balance function was significantly correlated with increased variability of step length and decreased sagittal ankle dorsiflexion ROM in the swing phase. The detailed gait pattern of WS children with impaired visuospatial recognition was presented. These findings show that impaired visuospatial recognition and balance function contribute to gait adaptation.