Role of the C region in relative growth rates of endogenous and exogenous avian oncoviruses.
Role of the C region in relative growth rates of endogenous and exogenous avian oncoviruses.
复制标题
C 区在内源性和外源性禽肿瘤病毒相对生长速率中的作用。
DOI：
10.1101/sqb.1980.044.01.121
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Coffin,JM
中科院分区：
文献类型：
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作者：
Tsichlis,PN;Coffin,JM
禽流感病毒可分为两类：(1)可自发表达或可从正常未感染的鸡细胞中诱导产生的内源性病毒(见Robinson 1978)，以及(2)最初从自发发生的鸡肿瘤中分离的外源病毒。表1显示了RAV-0的基因组成，它是一种典型的无缺陷鸡内源性病毒，也是三种主要外源病毒的代表：PRB RSV，一种无缺陷的转化病毒；tdPRB-RSV，一种与淋巴白血病病毒生物学上相同的转化缺陷(TD)突变体(尽管它可能在env和C之间有一个额外的序列)；以及MC29，一种有缺陷的急性白血病病毒。1978年；Neiman et al.1977)，将其70年代的基因组RNA与非缺陷肉瘤病毒的基因组RNA进行比较。这两个基因组在5‘端的半部分几乎完全相同(Gag和Pol1基因)。由于累积的碱基变化，env基因发生了显著的分化。在RAV-0基因组中不能检测到env和src之间的序列以及src基因序列。最后，两个病毒基因组3‘端聚(A)相邻的区域是不相关的。RAV-0的这个区域与迄今为止研究过的所有内源性病毒的区域几乎相同(P.Tsichlis等人，Unpubl.)与所有外源病毒非常不同，外源病毒也与一种
The avian oncoviruses can be divided into two distinct categories:(1) endogenous viruses that are spontaneously expressed or can be induced from normal uninfected chicken cells (for review, see Robinson 1978), and (2) exogenous viruses originally isolated from spontaneously arising chicken neoplasms. Table 1 shows the genetic constitution of RAV-0, a typical nondefective endogenous virus of chickens, and a representative of the three major types of exogenous virus: PRB RSV, a nondefective transforming virus; tdPRB-RSV, a transformation-defective (td) mutant of PRB RSV that is biologically identical to lymphoid leukosis virus (although it may have an additional sequence between env and C); and MC29, a defective acute leukemia virus.RAV-0 has been extensively studied in this laboratory and elsewhere (Coffin et al. 1978; Neiman et al. 1977) by comparison of its 70S genomic RNA with that of nondefective sarcoma virus. The two genomes are almost identical in the 5'half (gag and pol genes). The env genes have diverged significantly by accumulated base changes. A sequence between env and src and the src-gene sequence are not detectable in the genome of RAV-0. Finally, the regions adjacent to the poly (A) at the 3'end of the two viral genomes are unrelated. This region of RAV-0 is almost identical to that of all endogenous viruses so far studied (P. Tsichlis et al., unpubl.) and very different from that of all the exogenous viruses, which are also closely related to one