Organocatalytic synthesis of (2S,3R)-3-hydroxy-3-methyl-proline (OHMePro), a component of polyoxypeptins, and relatives using OHMePro itself as a catalyst.
Organocatalytic synthesis of (2S,3R)-3-hydroxy-3-methyl-proline (OHMePro), a component of polyoxypeptins, and relatives using OHMePro itself as a catalyst.
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DOI：
10.1021/ol0706004
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发表时间：
2007-05
期刊：
影响因子：
5.2
通讯作者：
Yayoi Yoshitomi;K. Makino;Y. Hamada
中科院分区：
文献类型：
--
作者：
Yayoi Yoshitomi;K. Makino;Y. Hamada
以(2S，3R)-3-羟基-3-甲基脯氨酸(OHMePro)为有机催化剂，实现了(2S，3R)-3-羟基-3-甲基脯氨酸(OHMePro)及其类似物的高效合成，其中酮醛的不对称Aldol反应是关键步骤。
An efficient synthesis of (2S,3R)-3-hydroxy-3-methylproline (OHMePro), a component of polyoxypeptins, and relatives was achieved, in which an intramolecular asymmetric aldol reaction of the ketoaldehyde using OHMePro itself as an organocatalyst constitutes a key step.