A multivariate metabolic imaging marker for behavioral variant frontotemporal dementia.
A multivariate metabolic imaging marker for behavioral variant frontotemporal dementia.
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DOI：
10.1016/j.dadm.2018.07.009
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发表时间：
2018-01-01
期刊：
影响因子：
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通讯作者：
Eidelberg, David
中科院分区：
文献类型：
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作者：
Nazem, Amir;Tang, Chris C;Eidelberg, David
简介：异质性的行为变异额颞叶痴呆症（bvFTD）要求多变量成像biomarkers.METHODS：我们研究了共148例痴呆症患者从范斯坦研究所（中心A：25 bvFTD和10阿尔茨海默氏病），技术大学的慕尼黑（中心B：44 bvFTD和29 FTD的语言变体），和阿尔茨海默氏病神经影像学倡议（40阿尔茨海默氏病的主题）。为了确定bvFTD（行为变异型额颞叶痴呆相关模式[bFDRP]）的协方差模式，我们对bvFTD和健康受试者的18 F-氟脱氧葡萄糖-正电子发射断层扫描进行了主成分分析。结果：bFDRP在A中心数据中被鉴定（受试者 * 体素方差的24.1%;
INTRODUCTION: The heterogeneity of behavioral variant frontotemporal dementia (bvFTD) calls for multivariate imaging biomarkers.METHODS: We studied a total of 148 dementia patients from the Feinstein Institute (Center-A: 25 bvFTD and 10 Alzheimer's disease), Technical University of Munich (Center-B: 44 bvFTD and 29 FTD language variants), and Alzheimer's Disease Neuroimaging Initiative (40 Alzheimer's disease subjects). To identify the covariance pattern of bvFTD (behavioral variant frontotemporal dementia-related pattern [bFDRP]), we applied principal component analysis to combined 18F-fluorodeoxyglucose-positron emission tomography scans from bvFTD and healthy subjects. The phenotypic specificity and clinical correlates of bFDRP expression were assessed in independent testing sets.RESULTS: The bFDRP was identified in Center-A data (24.1% of subject*voxel variance; P