PER3 Polymorphism and Insomnia Severity in Alcohol Dependence
PER3 Polymorphism and Insomnia Severity in Alcohol Dependence
复制标题
DOI：
10.5665/sleep.1748
复制
发表时间：
2012-04-01
期刊：
影响因子：
5.6
通讯作者：
Burmeister, Margit
中科院分区：
文献类型：
--
作者：
Brower, Kirk J.;Wojnar, Marcin;Burmeister, Margit
研究目的：酒精依赖（AD）患者中，酒精依赖是常见的、持续性的，并与复发相关。尽管其潜在机制大多未被研究，但AD患者的昼夜节律和睡眠驱动力受损，这可能受到遗传影响。PER 3基因的多态性（PER 3（4/4）、PER 3（4/5）、PER 3（5/5））先前已与昼夜节律偏好和睡眠稳态相关，并且PER 3（4/4）基因型的特征在于晚上偏好和睡眠驱动力降低。本研究的目的是研究这种多态性对AD患者失眠严重程度的影响。我们假设PER 3多态性是失眠严重程度的独立预测因子，在PER 3（4/4）genotype.Design中观察到的最严重程度是患者特征、基因型和失眠严重程度的横断面相关性。显著（P < 0.05）双变量相关性通过分层、强制输入多元线性回归进一步分析。设置：波兰华沙的酒精治疗项目。患者：根据精神障碍诊断和统计手册第4版诊断为酒精依赖（n = 285）。测量和结果：饮酒频率、精神和身体健康状况、儿童期虐待和PER 3基因型是失眠严重程度的独立预测因子，通过睡眠障碍问卷的7项子量表测量，解释了28.9%的方差。在最后一步中加入基因型显著增加了1.1%的方差解释量（P = 0.027）。结论：PER 3基因型在预测AD患者失眠严重程度方面具有独特的变异性。这些结果是一致的遗传影响的损害，在睡眠调节机制的AD患者失眠。
Study Objectives: Insomnia is common, persistent, and associated with relapse in alcohol-dependent (AD) patients. Although the underlying mechanisms are mostly unstudied, AD patients have impaired circadian rhythms and sleep drive, which may be genetically influenced. A polymorphism in the PER3 gene (PER3(4/4), PER3(4/5), PER3(5/5)) has previously been associated with circadian preference and sleep homeostasis, and the PER3(4/4) genotype has been characterized by evening preference and decreased sleep drive. The purpose of this study was to examine the influence of this polymorphism on insomnia severity in AD patients. We hypothesized that the PER3 polymorphism would be an independent predictor of insomnia severity with greatest severity observed in those with the PER3(4/4) genotype.Design: Cross-sectional association of patient characteristics, genotype, and insomnia severity. Significant (P < 0.05) bivariate correlates were further analyzed by hierarchical, forced entry multiple linear regression.Setting: Alcohol treatment programs in Warsaw, Poland.Patients: Diagnosed with alcohol dependence (n = 285), according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition.Measurements and Results: Drinking frequency, mental and physical health status, childhood abuse, and PER3 genotype were independent predictors of insomnia severity, as measured by a 7-item subscale of the Sleep Disorders Questionnaire, explaining 28.9% of the variance. Addition of the genotype in the final step significantly increased the amount of variance explained by 1.1% (P = 0.027). Those with the PER3(4/4) genotype had the greatest severity of insomnia symptoms.Conclusions: PER3 genotype contributed unique variance in predicting insomnia severity in AD patients. These results are consistent with genetically influenced impairment in sleep regulation mechanisms in AD patients with insomnia.