Reproducibility of four-dimensional computed tomography-based lung ventilation imaging.
Reproducibility of four-dimensional computed tomography-based lung ventilation imaging.
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DOI：
10.1016/j.acra.2012.07.006
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发表时间：
2012-12
影响因子：
4.8
通讯作者：
Keall PJ
中科院分区：
文献类型：
--
作者：
Yamamoto T;Kabus S;von Berg J;Lorenz C;Chung MP;Hong JC;Loo BW Jr;Keall PJ
一种新的基于四维(4D)CT的通风成像方法已应用于放射肿瘤学领域。了解其重复性是临床应用的前提。本研究的目的是量化不同天数和同一时段的4D CT通风成像的重复性。根据6名肺癌患者平均15天和6名患者5分钟的平均时间范围内获得的重复4D CT扫描，创建了两个通风图像。使用所有肺体素的基于体素的Spearman等级相关系数和分割的高、中、低功能肺体积的空间重叠的Dice相似系数(DSC)来量化可重复性。此外，用线性回归的方法评估了作为呼吸深度测量指标的腹部活动范围变化与通气量变化之间的关系。两幅通气图的体素相关性为中等(0.50±0.15)。高功能肺(0.60±0.08)、中等功能肺(0.46±0.06)和低功能肺(0.58±0.09)的DSCs也处于中等水平。没有患者表现出很强的相关性。运动范围的变化与通气量的变化之间的关系是中等和显著的。我们在15天5分钟的时间框架内调查了4D CT通风成像的重复性，发现它只是中等的重复性。在4D CT扫描中，呼吸变异被发现降低了重复性。为了提高4D CT通风成像的可重复性，需要对4D CT成像进行改进。
A novel ventilation imaging method based on four-dimensional (4D) computed tomography (CT) has been applied to the field of radiation oncology. Understanding its reproducibility is a prerequisite for clinical applications. The purpose of this study was to quantify the reproducibility of 4D CT ventilation imaging over different days and the same session. Two ventilation images were created from repeat 4D CT scans acquired over the average time frames of 15 days for 6 lung cancer patients and 5 minutes for another 6 patients. The reproducibility was quantified using the voxel-based Spearman rank correlation coefficients for all lung voxels and Dice similarity coefficients (DSC) for the spatial overlap of segmented high-, moderate-, and low-functional lung volumes. Furthermore, the relationship between the variation in abdominal motion range as a measure of the depth of breathing and variation in ventilation was evaluated using linear regression. The voxel-based correlation between the two ventilation images was moderate on average (0.50 ± 0.15). The DSCs were also moderate for the high- (0.60 ± 0.08), moderate- (0.46 ± 0.06), and low-functional lung (0.58 ± 0.09). No patients demonstrated strong correlations. The relationship between the motion range variation and ventilation variation was found to be moderate and significant. We investigated the reproducibility of 4D CT ventilation imaging over the time frames of 15 days and 5 minutes and found that it was only moderately reproducible. Respiratory variation during 4D CT scans was found to deteriorate the reproducibility. Improvement of 4D CT imaging is necessary to increase the reproducibility of 4D CT ventilation imaging.