ALOHOMORA:: a tool for linkage analysis using 10K SNP array data
ALOHOMORA:: a tool for linkage analysis using 10K SNP array data
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DOI：
10.1093/bioinformatics/bti264
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发表时间：
2005-05-01
期刊：
影响因子：
5.8
通讯作者：
Nürnberg, P
中科院分区：
文献类型：
--
作者：
Rüschendorf, F;Nürnberg, P
ALOHOMORA是一种软件工具，旨在促进使用高密度单核苷酸多态性（SNP）标记面板（如Affyssin GeneChip（R）Human Mapping 10K Array）进行的全基因组连锁研究。基因型数据被转换成适当的格式，用于许多常见的连锁程序，并在连锁运行开始前进行标准质量控制程序。ALOHOMORA是用Perl编写的，可用于在具有任何遗传模型的小型和大型家族中进行最先进的连锁扫描。使用不同的遗传图谱或种族特异性等位基因频率的选项被实现。提供了整个数据集以及单个家族的全基因组多点LOD评分值的图形输出。
ALOHOMORA is a software tool designed to facilitate genome-wide linkage studies performed with high-density single nucleotide polymorphism (SNP) marker panels such as the Affymetrix GeneChip (R) Human Mapping 10K Array. Genotype data are converted into appropriate formats for a number of common linkage programs and subjected to standard quality control routines before linkage runs are started. ALOHOMORA is written in Perl and may be used to perform state-of-the-art linkage scans in small and large families with any genetic model. Options for using different genetic maps or ethnicity-specific allele frequencies are implemented. Graphic outputs of whole-genome multipoint LOD score values are provided for the entire dataset as well as for individual families.