Polarity-independent effects of transcranial direct current stimulation over the bilateral opercular somatosensory region: a magnetoencephalography study.
Polarity-independent effects of transcranial direct current stimulation over the bilateral opercular somatosensory region: a magnetoencephalography study.
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DOI：
10.1097/wnr.0000000000000845
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发表时间：
2017-09-06
期刊：
影响因子：
1.7
通讯作者：
Sadato N
中科院分区：
文献类型：
--
作者：
Nakagawa K;Koyama S;Inui K;Tanaka S;Kakigi R;Sadato N
鳃盖部躯体感觉区（OP）在疼痛感知中起着不可或缺的作用。在本研究中，我们研究了经颅直流电刺激（tDCS）的神经生理效应OP。体感诱发磁场后，伤害性表皮内电刺激左手食指（疼痛SEFs）之前和之后tDCS记录单盲，假对照，交叉试验设计。应用左阳极/右阴极tDCS、左阴极/右阳极tDCS（各，2 mA，12 min）和假tDCS（2 mA，15 s）的三种tDCS条件。尽管主观疼痛感觉没有改变，但两种阳极（真实的）干预显著降低了与疼痛SEF相关的OP活动。总之，采用当前参数的OP上的tDCS对痛觉没有显著影响，但调节了其皮层处理。
The opercular somatosensory region (OP) plays an indispensable role in pain perception. In the present study, we investigated the neurophysiological effects of transcranial direct current stimulation (tDCS) over the OP. Somatosensory-evoked magnetic fields following noxious intraepidermal electrical stimulation to the left index finger (pain-SEFs) were recorded before and after tDCS with a single-blind, sham-controlled, cross-over trial design. Three tDCS conditions of left anodal/right cathodal tDCS, left cathodal/right anodal tDCS (each, 2 mA, 12 min), and sham tDCS (2 mA, 15 s) were applied. Despite the subjective pain sensation being unaltered, the two anodal (real) interventions significantly decreased OP activity associated with pain-SEFs. In conclusion, tDCS over the OP with the present parameters did not have a significant impact on pain sensation, but modulated its cortical processing.