Chronic Social Defeat Stress Modulates Dendritic Spines Structural Plasticity in Adult Mouse Frontal Association Cortex.
Chronic Social Defeat Stress Modulates Dendritic Spines Structural Plasticity in Adult Mouse Frontal Association Cortex.
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DOI：
10.1155/2017/6207873
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发表时间：
2017
影响因子：
3.1
通讯作者：
Xu T
中科院分区：
文献类型：
--
作者：
Shu Y;Xu T
慢性应激与许多精神障碍的发生有关。先前的研究表明，经历慢性应激后，前额叶皮质的锥体神经元的树突和棘突会发生剧烈的重组。因此，前额叶皮质被认为在神经系统对慢性应激的反应中起着关键作用。然而，应激如何诱导前额叶皮质神经回路的动态结构变化仍然未知。在本研究中，我们利用双光子显微镜在体内研究了慢性社会挫败应激对小鼠额叶联合（FrA）皮质树突棘结构可塑性的影响。我们发现慢性应激改变了FrA中的棘突动力学，并增加了FrA神经回路的连接性。我们还发现FrA中棘突动力学的变化与受挫小鼠的蔗糖偏好缺失相关。我们的研究结果表明，慢性应激经历导致神经回路的适应性改变，这可能对编码与应激经历相关的记忆和快感缺失很重要。
Chronic stress is associated with occurrence of many mental disorders. Previous studies have shown that dendrites and spines of pyramidal neurons of the prefrontal cortex undergo drastic reorganization following chronic stress experience. So the prefrontal cortex is believed to play a key role in response of neural system to chronic stress. However, how stress induces dynamic structural changes in neural circuit of prefrontal cortex remains unknown. In the present study, we examined the effects of chronic social defeat stress on dendritic spine structural plasticity in the mouse frontal association (FrA) cortex in vivo using two-photon microscopy. We found that chronic stress altered spine dynamics in FrA and increased the connectivity in FrA neural circuits. We also found that the changes in spine dynamics in FrA are correlated with the deficit of sucrose preference in defeated mice. Our findings suggest that chronic stress experience leads to adaptive change in neural circuits that may be important for encoding stress experience related memory and anhedonia.