Effects of hippocampal cholinergic deafferentation on learning strategy selection in a visible platform version of the water maze
Effects of hippocampal cholinergic deafferentation on learning strategy selection in a visible platform version of the water maze
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DOI：
10.1002/hipo.10113
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发表时间：
2003-01-01
期刊：
影响因子：
3.5
通讯作者：
Gallagher, M
中科院分区：
文献类型：
--
作者：
Bizon, JL;Han, JS;Gallagher, M
最近的证据表明，脑结构之间乙酰胆碱（ACh）的相对水平可能是在海马或背侧纹状体脑系统可以有效和独立使用的环境中选择行为策略的重要因素（McIntyre和Gold. 1999. Soc Neurosci Abs 25：1388）。目前的研究使用神经毒素192 IgG-皂草素选择性地消耗海马中的ACh，而在其他脑区（包括背侧纹状体）中留下ACh。然后在一种版本的莫里斯水迷宫上训练大鼠，其中归因于海马和背侧纹状体的行为策略被置于直接竞争中。推测海马ACh耗竭的大鼠会表现出线索偏向。与此预测相反，耗尽海马乙酰胆碱没有偏见，事实上，促进使用海马的地方战略在这项任务中，所示的选择在竞争测试和性能隐藏的平台训练试验。这些数据增加了越来越多的文献表明，隔海马胆碱能系统是不需要准确的空间学习，并建议一个复杂的作用，基底前脑预测在处理有关空间环境的信息。(C)2003 Wiley-Liss，Inc.
Recent evidence has suggested that the relative levels of acetylcholine (ACh) between brain structures may be an important factor in the choice of behavioral strategy in settings in which either hippocampal or dorsal striatal brain systems can be employed both effectively and independently (McIntyre and Gold. 1999. Soc Neurosci Abs 25:1388). The current investigation used the neurotoxin 192 IgG-saporin to deplete the hippocampus of ACh selectively, while leaving ACh in other brain regions, including dorsal striatum, intact. Rats were then trained on a version of the Morris water maze, in which behavioral strategies attributed to the hippocampus and dorsal striatum are placed in direct competition. It was predicted that rats with hippocampal ACh depletion would display a cue bias. Contrary to this prediction, depleting hippocampal ACh did not bias against and, in fact, promoted use of a hippocampal place strategy in this task, as indicated by choice in competition tests and performance on hidden platform training trials. These data add to a growing literature demonstrating that the septohippocampal cholinergic system is not required for accurate spatial learning and suggest a complex role for basal forebrain projections in processing information about the spatial environment. (C) 2003 Wiley-Liss, Inc.