Increasing health burden of human babesiosis in endemic sites
Increasing health burden of human babesiosis in endemic sites
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DOI：
10.4269/ajtmh.2003.68.431
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发表时间：
2003-04-01
影响因子：
3.3
通讯作者：
Spielman, A
中科院分区：
文献类型：
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作者：
Krause, PJ;McKay, K;Spielman, A
由田鼠巴贝虫引起的人类感染被认为是罕见的，并且是一种主要影响老年人或免疫功能低下的疾病。为了确定是否在地方性地点的风险可能会增加相对于伯氏疏螺旋体，并确定其年龄相关的临床谱，我们进行了为期10年的社区为基础的血清学调查和病例发现研究，罗得岛的布洛克岛。在附近的地点进行了不太密集的观察。在1990年代早期，布洛克岛上巴贝斯虫感染的发病率增加，达到了疏螺旋体感染的四分之三左右。布洛克岛居民中约有十分之一的血清对巴贝斯虫抗原有反应，血清阳性率与普鲁登斯岛和康涅狄格州东南部的血清阳性率相似。尽管50岁以上人群的巴贝斯虫症状数量和持续时间与20至49岁人群相似，但住院的老年人比年轻人多。很少有感染巴贝西亚的儿童住院。在新英格兰南部的地方性地点，巴贝斯虫的发病率似乎在20世纪90年代上升到接近由于疏螺旋体病的水平。
Human infection due to Babesia microti has been regarded as infrequent and a condition primarily affecting the elderly or immunocompromised. To determine whether risk in endemic sites may be increasing relative to that of Borrelia burgdorferi and to define its age-related clinical spectrum, we carried out a 10-year community-based serosurvey and case finding study on Block Island, Rhode Island. Less intensive observations were conducted in nearby sites. Incidence of babesial infection on Block Island increased during the early 1990s, reaching a level about three-fourths that of borrelial infection. The sera of approximately one-tenth of Block Island residents reacted against babesial antigen, a seroprevalence similar to those on Prudence Island and in southeastern Connecticut. Although the number and duration of babesial symptoms in people older than 50 years of age approximated those in people 20 to 49 years of age, more older adults were admitted to hospital than younger adults. Few Babesia-infected children were hospitalized. Babesial incidence at endemic sites in southern New England appears to have risen during the 1990s to a level approaching that due to borreliosis.