Quantitative magnetic resonance imaging of the brain in survivors of very low birth weight
Quantitative magnetic resonance imaging of the brain in survivors of very low birth weight
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DOI：
10.1136/adc.87.4.279
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发表时间：
2002-10-01
影响因子：
5.2
通讯作者：
Cooke, RWI
中科院分区：
文献类型：
--
作者：
Abernethy, LJ;Palaniappan, M;Cooke, RWI
背景：没有严重残疾的极低出生体重 (VLBW) 儿童的学习困难、注意力缺陷和运动障碍的患病率很高。目的：确定 VLBW 儿童的学习困难是否与大脑结构异常相关。方法：对 87 名有 VLBW 病史（< 1500 g）的儿童（15-16 岁）和 8 名年龄匹配的足月对照儿童进行了详细的磁共振脑扫描研究。对尾状核和海马结构进行了体积测量。结果：42.5% 的儿童扫描显示围产期脑损伤的证据。扫描质量正常和异常的儿童在智商、运动障碍或注意力缺陷方面没有显着差异。然而，定量体积分析显示，与智商正常儿童相比，低智商儿童的右侧尾状核和左侧海马体积较小，海马比例（左侧体积：右侧体积）较小。结论：数据表明，VLBW存活儿童的学习障碍、注意力缺陷和运动障碍与围生期大脑的常规标志物不相关。损伤，并且可能与整体大脑生长和关键结构的发育有关，例如尾状核和海马结构。
Background: Children who survive very low birth weight (VLBW) without major disability have a high prevalence of learning difficulty, attention deficit, and dyspraxia.Aims: To determine whether learning difficulty in children with VLBW is associated with structural brain abnormalities.Methods: A total of 87 children (aged 15-16 years) with a history of VLBW (< 1500 g) and eight age matched full term controls have been studied with detailed magnetic resonance brain scans. Volume measurements of the caudate nuclei and hippocampal formations were made.Results: Scans in 42.5% of the children showed evidence of perinatal brain injury. There was no significant difference in IQ, dyspraxia, or attention deficit between children with qualitatively normal and abnormal scans, However, quantitative volumetric analysis showed that children with a low IQ had smaller volume measurements for the right caudate nucleus and left hippocampus, and a smaller hippocampal ratio (left volume:right volume) than those with normal IQ.Conclusion: Data suggest that learning disorder, attention deficit, and dysproxia in children who survive VLBW do not correlate with conventional markers of perinatal brain injury, and may be related to global brain growth and the development of key structures, such as the caudate nuclei and hippocampal formations.