Nonenzymatic kinetic resolution of racemic alcohols through an ''induced fit'' process
Nonenzymatic kinetic resolution of racemic alcohols through an ''induced fit'' process
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DOI：
10.1021/ja963275g
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发表时间：
1997-04-02
影响因子：
15
通讯作者：
Fuji, K
中科院分区：
文献类型：
--
作者：
Kawabata, T;Nagato, M;Fuji, K
通过酰化或脱酰化反应的外消旋醇的酶促动力学拆分已被广泛研究1，并被确立为制备光学活性醇的最有效方法之一。2最近还开发了该领域的非酶替代品。使用化学计量的手性酰化剂影响高立体选择性的动力学拆分。3另一方面，相应的催化过程仍处于发展阶段。Vedejs等人报道了第一个实例，手性膦催化促进9- 81%ee的动力学拆分（s值4
Enzymatic kinetic resolution of racemic alcohols through acylation or deacylation has been extensively studied1 and established as one of the most effective methods for the preparation of optically active alcohols. 2 Nonenzymatic alternatives in this field have also been developed recently. Use of stoichiometric amounts of chiral acylating agents effected the kinetic resolution with high stereoselectivity. 3 On the other hand, the corresponding catalytic process is still in the developmental stage. The first example was reported by Vedejs et al. that chiral phosphines catalytically promoted the kinetic resolution in 9-81% ee (s value4