DHX37 Impacts Prognosis of Hepatocellular Carcinoma and Lung Adenocarcinoma through Immune Infiltration.
DHX37 Impacts Prognosis of Hepatocellular Carcinoma and Lung Adenocarcinoma through Immune Infiltration.
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DHX37 通过免疫浸润影响肝细胞癌和肺腺癌的预后
DOI：
10.1155/2020/8835393
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发表时间：
2020
影响因子：
4.1
通讯作者：
Luo B
中科院分区：
文献类型：
--
作者：
Xu Y;Jiang Q;Liu H;Xiao X;Yang D;Saw PE;Luo B
背景RNA解旋酶在RNA代谢的各个方面都具有重要的功能，不仅可以解旋RNA，还可以干扰RNA与蛋白质的相互作用。最近，RNA解旋酶被认为是癌症的潜在靶点。到目前为止，还没有关于RNA解旋酶DHX37在癌症中的生物学功能的详细研究。目的探讨DHX37与肿瘤微环境的关系及其在肿瘤预后中的价值。方法通过Oncomine数据库和肿瘤免疫评估资源（TIMER）检测DHX37的表达。我们在各种数据库中探索了DHX37在癌症中的预后作用。共表达基因、基因本体论（GO）和基因和基因组的京都百科全书（KEGG）以及基本调控因子通过LinkedOmics进行。为了证实DHX37在肝细胞癌（LIHC）和肺腺癌（LUAD）中的预后价值，我们使用基因表达谱交互分析（GEPIA）和TIMER数据库探索了DHX37在癌症浸润淋巴细胞中的作用。结果通过GO和KEGG分析，DHX37的表达也与涉及核糖体和RNA代谢信号通路的复杂功能特异性网络相关。在LIHC和LUAD中，DHX37的表达与T细胞标志物、髓源性抑制细胞（MDSC）和T细胞耗竭呈显著正相关，有助于免疫耐受。结论DHX37可作为LIHC和LUAD的预后生物标志物，并通过激活T淋巴细胞、MDSC和T细胞耗竭在免疫耐受中发挥重要作用。
Background RNA helicases have various essential functions in basically all aspects of RNA metabolism, not only unwinding RNA but also disturbing the interaction of RNA with proteins. Recently, RNA helicases have been considered potential targets in cancers. So far, there has been no detailed investigation of the biological functions of RNA helicase DHX37 in cancers. Objective We aim to identify the prognostic value of DHX37 associated with tumor microenvironments in cancers. Methods DHX37 expression was examined via the Oncomine database and Tumor Immune Estimation Resource (TIMER). We explored the prognostic role of DHX37 in cancers across various databases. Coexpression genes, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), and fundamental regulators were performed via LinkedOmics. Confirming the prognostic value of DHX37 in liver hepatocellular carcinoma (LIHC) and lung adenocarcinoma (LUAD), we explored the role of DHX37 in infiltrated lymphocytes in cancers using the Gene Expression Profiling Interactive Analysis (GEPIA) and TIMER databases. Results Through GO and KEGG analyses, expression of DHX37 was also correlated with complex function-specific networks involving the ribosome and RNA metabolic signaling pathways. In LIHC and LUAD, DHX37 expression showed significant positive correlations with markers of Tregs, myeloid-derived suppressor cells (MDSCs), and T cell exhaustion, contributing to immune tolerance. Conclusion These results indicate that DHX37 can serve as a prognostic biomarker in LIHC and LUAD while having an important role in immune tolerance by activating the function of Tregs, MDSC, and T cell exhaustion.
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影响因子：
4.1
作者：
Huang B;Zhang H;Gu L;Ye B;Jian Z;Stary C;Xiong X
通讯作者：
Xiong X
DOI：
10.1016/j.bbrc.2013.12.021
发表时间：
2014-01-10
影响因子：
3.1
作者：
Cambiaghi, Tavane D.;Pereira, Catia M.;Castilho, Beatriz A.
通讯作者：
Castilho, Beatriz A.
影响因子：
15.9
作者：
Huber, Veronica;Vallacchi, Viviana;Rivoltini, Licia
通讯作者：
Rivoltini, Licia
影响因子：
64.5
作者：
Dong, Matthew B.;Wang, Guangchuan;Chen, Sidi
通讯作者：
Chen, Sidi
影响因子：
20.3
作者：
Lewinsohn, Maya;Brown, Anna L.;Scott, Hamish S.
通讯作者：
Scott, Hamish S.