Impact of intermittent hypoxia on long-term facilitation of minute ventilation and heart rate variability in men and women: do sex differences exist?
Impact of intermittent hypoxia on long-term facilitation of minute ventilation and heart rate variability in men and women: do sex differences exist?
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DOI：
10.1152/japplphysiol.01273.2007
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发表时间：
2008-06-01
影响因子：
3.3
通讯作者：
Mateika, Jason H.
中科院分区：
文献类型：
--
作者：
Wadhwa, Harpreet;Gradinaru, Ciprian;Mateika, Jason H.
暴露于间歇性缺氧后，呼吸运动活动和交感神经系统活动可能持续超过一个小时。本研究的目的是确定是否持续增加分钟通气量和交感迷走神经（S/V）平衡，除了持续抑制副交感神经系统活动（PNSA），男性比女性暴露于间歇性缺氧。15名年龄、种族和体重指数相匹配的健康男性和女性在持续高碳酸血症期间暴露于8次4分钟的低氧发作，随后是15分钟的终末恢复期。与基线相比，恢复末期每分钟通气量增加的幅度在男性和女性中相似（男性，1.52 +/- 0.03;女性，1.57 +/- 0.02基线分数; P < 0.0001）。相反，与基线相比，在男性中，在恢复期结束时，PNSA的抑制和S/V平衡的增加是明显的（PNSA，基线的0.66 +/- 0.06分数，P < 0.0001; S/V平衡，基线的2.8 +/-0.7分数，P < 0.03），但女性中没有（PNSA，基线的1.27 +/- 0.19分数，P = 0.3; S/V平衡，基线的1.8 +/- 0.6分数，P = 0.2）。我们的结论是持续增加分钟通气量，这是长期的促进，是明显的男性和女性暴露于间歇性缺氧，这种反应是独立的性别。相反，持续的自主神经系统活动的变化在男性中很明显，但在女性中则不明显。
Following exposure to intermittent hypoxia, respiratory motor activity and sympathetic nervous system activity may persist above baseline levels for over an hour. The present investigation was designed to determine whether sustained increases in minute ventilation and sympathovagal (S/V) balance, in addition to sustained depression of parasympathetic nervous system activity (PNSA), were greater in men compared with women following exposure to intermittent hypoxia. Fifteen healthy men and women matched for age, race, and body mass index were exposed to eight 4-min episodes of hypoxia during sustained hypercapnia followed by a 15-min end-recovery period. The magnitude of the increase in minute ventilation during the endrecovery period, compared with baseline, was similar in men and women (men, 1.52 +/- 0.03; women, 1.57 +/- 0.02 fraction of baseline; P < 0.0001). In contrast, depression of PNSA and increases in S/V balance were evident during the end-recovery period, compared with baseline, in men (PNSA, 0.66 +/- 0.06 fraction of baseline, P < 0.0001; S/V balance, 2.8 +/- 0.7 fraction of baseline, P < 0.03) but not in women (PNSA, 1.27 +/- 0.19 fraction of baseline, P = 0.3; S/V balance, 1.8 +/- 0.6 fraction of baseline, P = 0.2). We conclude that a sustained increase in minute ventilation, which is indicative of long-term facilitation, is evident in both men and women following exposure to intermittent hypoxia and that this response is independent of sex. In contrast, sustained alterations in autonomic nervous system activity were evident in men but not in women.