Development of cerebral microbleeds and its impact on cognitive function in adult patients receiving medical management alone for ischemic moyamoya disease: supplementary analysis of a 5-year prospective cohort.
Development of cerebral microbleeds and its impact on cognitive function in adult patients receiving medical management alone for ischemic moyamoya disease: supplementary analysis of a 5-year prospective cohort.
复制标题
接受单独药物治疗的缺血性烟雾病成年患者脑微出血的发生及其对认知功能的影响：5 年前瞻性队列的补充分析。
DOI：
10.1080/01616412.2022.2112375
复制
发表时间：
2022
期刊：
影响因子：
1.9
通讯作者：
Ogasawara K.
中科院分区：
文献类型：
--
作者：
Yabuki M;Kubo Y;Kitakami K;Oomori D;Fujiwara S;Yoshida K;Kobayashi M;Ogasawara K.
T2* 加权磁共振成像（MRI）显示的新发脑微出血（CMB）在成人烟雾病（MMD）中随时间推移而发生，通常与整体认知功能下降相关。本补充分析的5年前瞻性队列旨在阐明的发病率间隔增加CMB的成年患者接受单独的医疗管理缺血性MMD及其对认知功能的影响。Methods 64例患者没有痛苦灌注在症状性大脑半球纳入谁没有经历任何进一步的缺血症状或新的出血事件在5年的后续-期间进行了T2* 加权MRI和五种神经心理学测试在列入和5年follow-up.ResultsWhen T2* 加权MRI进行了比较之间的列入和5年的随访结束时，10例（15%）有一个时间间隔增加CMB在症状的大脑半球列入。在5年随访结束时，两种神经心理学测试的得分与入选时相比，在CMB间隔增加的患者中显着恶化，而在5年随访结束时，四种神经心理学测试的得分与入选时相比，在没有CMB间隔增加，无症状缺血性病变，或血管造影疾病进展。ConclusionsThe发病率的间隔增加CMB是15%，每5年接受单独的医疗管理缺血性MMD的成年患者，这种增加与认知能力下降下降。
ObjectiveDe novo cerebral microbleeds (CMBs) on T2*-weighted magnetic resonance imaging (MRI) develop over time in adult moyamoya disease (MMD) and are generally associated with a decline in global cognitive function. The present supplementary analysis of a 5-year prospective cohort aimed to elucidate the incidence of an interval increase in CMBs in adult patients receiving medical management alone for ischemic MMD and its impact on cognitive function.MethodsSixty-four patients without misery perfusion in the symptomatic cerebral hemispheres at inclusion who did not experience any further ischemic symptoms or new hemorrhagic events during a 5-year follow-up period underwent T2*-weighted MRI and five kinds of neuropsychologic tests at inclusion and the end of the 5-year follow-up.ResultsWhen T2*-weighted MRI was compared between inclusion and the end of the 5-year follow-up, 10 patients (15%) had an interval increase in CMBs in the symptomatic cerebral hemisphere at inclusion. The scores from two kinds of neuropsychologic tests significantly deteriorated at the end of the 5-year follow-up compared with those at inclusion in patients with an interval increase in CMBs, whereas the scores of four kinds of neuropsychologic tests significantly improved at the end of the 5-year follow-up compared with those at inclusion in patients without interval increases in CMBs, asymptomatic ischemic lesions, or angiographic disease progression.ConclusionsThe incidence of an interval increase in CMBs was 15% per 5 years in adult patients receiving medical management alone for ischemic MMD, and this increase was associated with a decline in cognitive decline.