Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?
Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?
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DOI：
10.1007/s12079-009-0037-7
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发表时间：
2009-06
影响因子：
4.1
通讯作者：
Abraham, D. J.
中科院分区：
文献类型：
--
作者：
Leask, Andrew;Parapuram, Sunil K.;Xu Shi-wen;Abraham, D. J.
CCN（CCN 61，ctgf，nov）模块蛋白家族调节多种生物学作用，包括细胞粘附、基质产生、组织重塑、增殖和分化。最近的靶向基因破坏研究表明，CCN家族对软骨形成、骨生成和血管生成是发育必需的。CCN 2由诸如血管紧张素II、内皮素-1、糖皮质激素、HGF、TGFβ和VEGF的试剂以及由缺氧和生物力学和剪切应力诱导。在许多纤维增生性疾病中也广泛记录了CCN 2的表达失调。本文将重点介绍CCN 2，以及最近在了解CCN 2基因调控健康和疾病方面的进展。CCN 2应被认为是一种新的和翔实的替代临床生物标志物的纤维增生性疾病进行了讨论。
The CCN (cyr61, ctgf, nov) family of modular proteins regulate diverse biological affects including cell adhesion, matrix production, tissue remodelling, proliferation and differentiation. Recent targeted gene disruption studies have demonstrated the CCN family to be developmentally essential for chondrogenesis, osteogenesis and angiogenesis. CCN2 is induced by agents such as angiotensin II, endothelin-1, glucocorticoids, HGF, TGFβ, and VEGF, and by hypoxia and biomechanical and shear stress. Dysregulated expression of CCN2 has also been widely documented in many fibroproliferative diseases. This mini-review will focus on CCN2, and the recent progress in understanding CCN2 gene regulation in health and disease. That CCN2 should be considered a novel and informative surrogate clinical bio-marker for fibroproliferative disease is discussed.
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影响因子：
4.8
作者：
Abraham, DJ;Xu, SW;Leask, A
通讯作者：
Leask, A
影响因子：
13.3
作者：
Dziadzio, M;Usinger, W;Stratton, R
通讯作者：
Stratton, R
DOI：
10.1083/jcb.114.6.1285
发表时间：
1991-09
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bradham DM;Igarashi A;Potter RL;Grotendorst GR
通讯作者：
Grotendorst GR
影响因子：
4.1
作者：
Chen, Shaoqiong;McLean, Sarah;Leask, Andrew
通讯作者：
Leask, Andrew
影响因子：
9.3
作者：
Gressner, Axel M.;Yagmur, Eray;Stanzel, Sven
通讯作者：
Stanzel, Sven