Chronic enteroviral meningoencephalitis in agammaglobulinemic patients.
Chronic enteroviral meningoencephalitis in agammaglobulinemic patients.
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无丙种球蛋白血症患者的慢性肠道病毒性脑膜脑炎。
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
C. Wilfert
中科院分区：
文献类型：
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作者：
R. McKinney;S. Katz;C. Wilfert
无丙种球蛋白血症患者特别容易受到中枢神经系统慢性肠道病毒感染。通过文献查阅、与其他医生的交流以及个人经验获得了 42 名患者的数据。 38 名患者患有先天性免疫缺陷，最常见的是 X 连锁无丙种球蛋白血症。大多数可评估的患者在肠道病毒感染前正在接受肌内丙种球蛋白维持治疗。七名患者在感染前未被识别为低丙种球蛋白血症。最常见的病原体是埃可病毒（41 例中的 37 例），尤其是 11 型（11 例）。迄今为止，已有四名患者相继或同时感染了第二种肠道病毒血清型。该疾病的其他特征包括虚弱、嗜睡或昏迷、头痛、听力丧失、癫痫发作、共济失调和感觉异常。一些患者还出现慢性肠道病毒感染的非神经系统表现，包括发烧、皮肌炎样综合征、水肿、皮疹和肝炎。治疗主要包括静脉注射免疫球蛋白制剂或免疫血浆中的抗体给药。 12 名患者通过储存装置接受了脑室内免疫球蛋白；根据临床标准判断，这 12 项中的 6 项已得到显着改善。
Patients with agammaglobulinemia are particularly susceptible to chronic enteroviral infections of the central nervous system. Data on 42 patients were obtained by literature review, communications with other physicians, and personal experiences. Thirty-eight patients had congenital immunodeficiencies, most frequently X-linked agammaglobulinemia. Most patients who could be assessed were receiving maintenance therapy with intramuscular gamma-globulin before their enteroviral infection. Seven patients had not been recognized as hypogammaglobulinemic before the onset of infection. The commonest pathogens were echoviruses (37 of 41 cases), especially type 11 (11 cases). Thus far, four patients have had sequential or simultaneous infections with a second enteroviral serotype. Other features of the disease have included weakness, lethargy or coma, headaches, hearing loss, seizures, ataxia, and paresthesias. Some patients have also had nonneurologic manifestations of chronic enteroviral infection, including fever, the dermatomyositis-like syndrome, edema, rashes, and hepatitis. Treatment has consisted primarily of antibody administration, either in intravenous immunoglobulin preparations or in immune plasma. Twelve patients have received intraventricular immunoglobulin through reservoir devices; six of these 12 have improved substantially, as judged by clinical criteria.
原发性和继发性免疫缺陷疾病中淋巴细胞分化的评估。
DOI：
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发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Tedder,TF;Crain,MJ;Kubagawa,H;Clement,LT;Cooper,MD
通讯作者：
Cooper,MD