The effects of probiotics plus dietary fiber on antipsychotic-induced weight gain: a randomized clinical trial.
The effects of probiotics plus dietary fiber on antipsychotic-induced weight gain: a randomized clinical trial.
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益生菌加膳食纤维对抗精神病药物引起的体重增加的影响：一项随机临床试验
DOI：
10.1038/s41398-022-01958-2
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发表时间：
2022-05-04
影响因子：
6.8
通讯作者：
Wu R
中科院分区：
文献类型：
--
作者：
Huang J;Liu C;Yang Y;Kang D;Xiao J;Long Y;Lang B;Peng X;Wang W;Wang X;Liu F;Zhao J;Shi Z;Yuan TF;Wu R
Probiotics plus dietary fiber has demonstrated efficacy in improving metabolic abnormalities. However, the efficacy of probiotics and dietary fiber as well as their association with microbiota in attenuating antipsychotic-induced weight gain and metabolic disturbance remains poorly understood. Here we analyzed results from the double-blind, randomized, placebo-controlled study to compare and evaluate the effects of probiotics, dietary fiber, and their combination for antipsychotic-induced weight gain in patients with a severe mental disorder. We found that probiotics plus dietary fiber was significantly superior to probiotics alone, dietary fiber only, and the placebo for weight, BMI, and total cholesterol reduction; insulin resistance was worse in the placebo group, with significant increases during the 12-week treatment; probiotics plus dietary fiber significantly reduced weight and prevented further deterioration of metabolic disturbances; and probiotics or dietary fiber alone can prevent further weight gain. We further performed 16 S ribosomal RNA sequencing revealed an increased abundance of microbiota after probiotics plus dietary fiber treatment. Moreover, logistic regression analyses revealed that the higher richness of microbiota was associated with favorable weight loss. These findings suggested that probiotics and dietary fiber co-administration were safe and effective interventions to reduce weight gain in patients treated with antipsychotic medications.
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影响因子：
11.1
作者：
Bahr SM;Weidemann BJ;Castro AN;Walsh JW;deLeon O;Burnett CM;Pearson NA;Murry DJ;Grobe JL;Kirby JR
通讯作者：
Kirby JR
影响因子：
2.5
作者：
Liu C;Kang D;Xiao J;Huang Y;Peng X;Wang W;Xie P;Yang Y;Zhao J;Wu R
通讯作者：
Wu R
影响因子：
29
作者：
Cignarella F;Cantoni C;Ghezzi L;Salter A;Dorsett Y;Chen L;Phillips D;Weinstock GM;Fontana L;Cross AH;Zhou Y;Piccio L
通讯作者：
Piccio L
影响因子：
6.8
作者：
Bahr SM;Tyler BC;Wooldridge N;Butcher BD;Burns TL;Teesch LM;Oltman CL;Azcarate-Peril MA;Kirby JR;Calarge CA
通讯作者：
Calarge CA
影响因子：
5.3
作者：
Marder, SR;Davis, JM;Chouinard, G
通讯作者：
Chouinard, G