Somatosensory input to auditory association cortex in the macaque monkey
Somatosensory input to auditory association cortex in the macaque monkey
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DOI：
10.1152/jn.2001.85.3.1322
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发表时间：
2001-03-01
影响因子：
2.5
通讯作者：
Javitt, DC
中科院分区：
文献类型：
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作者：
Schroeder, CE;Lindsley, RW;Javitt, DC
我们研究了猕猴听觉皮层内各亚区的躯体感觉和听觉输入的会聚。在三只猕猴的后上级颞平面穿透过程中，用线性阵列多电极采样层流电流源密度和多单位活动曲线。在每个记录站点，双耳点击，纯音，带通噪声，所有耳机呈现的听觉反应，与对侧正中神经刺激诱发的体感反应进行了比较。受试者是清醒的，但不需要区分刺激。通过绘制最佳频率和刺激偏好以及随后的组织学分析来确定A1和周围带状区域之间的边界。区域立即尾内侧A1有强大的体感反应corepresented与听觉反应。在这些地区，躯体感觉和听觉反应的配置文件有“前馈”模式，初始兴奋开始在板层4和蔓延到颗粒外板层。听觉和体感反应显示出高度的时间重叠。解剖重建表明，体感输入区包括，但可能不限于，尾内侧听觉联合皮层。正如早先报道的，该区域的听觉频率调谐曲线较宽，带通噪声响应大于纯音响应。在A1中未观察到体感反应。这些研究结果表明，在听觉皮层处理的早期阶段的多感觉整合的潜在的神经基板。
We investigated the convergence of somatosensory and auditory inputs in within subregions of macaque auditory cortex. Laminar current source density and multiunit activity profiles were sampled with linear array multielectrodes during penetrations of the posterior superior temporal plane in three macaque monkeys. At each recording site, auditory responses to binaural clicks, pure tones, and band-passed noise, all presented by earphones, were compared with somatosensory responses evoked by contralateral median nerve stimulation. Subjects were awake but were not required to discriminate the stimuli. Borders between A1 and surrounding belt regions were identified by mapping best frequency and stimulus preferences and by subsequent histological analysis. Regions immediately caudomedial to A1 had robust somatosensory responses corepresented with auditory responses. In these regions, both somatosensory and auditory response profiles had "feedforward" patterns; initial excitation beginning in Lamina 4 and spreading to extragranular laminae. Auditory and somatosensory responses displayed a high degree of temporal overlap. Anatomical reconstruction indicated that the somatosensory input region includes, but may not be restricted to, the caudomedial auditory association cortex. As was earlier reported for this region, auditory frequency tuning curves were broad and band-passed noise responses were larger than pure tone responses. No somatosensory responses were observed in A1. These findings suggest a potential neural substrate for multisensory integration at an early stage of auditory cortical processing.