Lithium treatment of mania: clinical characteristics, specificity of symptom change, and outcome.
Lithium treatment of mania: clinical characteristics, specificity of symptom change, and outcome.
复制标题
锂盐治疗躁狂症：临床特征、症状变化的特异性和结果。
DOI：
10.1016/0165-1781(86)90025-9
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发表时间：
1986
影响因子：
11.3
通讯作者：
Robins,E
中科院分区：
文献类型：
--
作者：
Swann,AC;Secunda,SK;Katz,MM;Koslow,SH;Maas,JW;Chang,S;Robins,E
作为国家心理健康研究所抑郁症心理生物学合作研究的一部分，对 18 名躁狂患者的锂治疗效果和反应预测进行了研究。使用躁狂症诊断和严重程度量表（MADS）以及为测量抑郁症患者的状态和药物反应而开发的一系列行为结构对患者进行评级。约67%的患者在26天的锂治疗后获得了良好的治疗结果。治疗前，有反应者与无反应者在妄想、幻觉或烦躁偏执症状方面没有差异。在治疗前，无反应者比有反应者更加焦虑，并且在汉密尔顿抑郁量表上得分更高。然而，MADS 的改善与治疗前的行为评分无关。无论 MADS 评分如何变化，对非躁狂特定行为方面评分相对较高的患者往往在这些方面有所改善。同时患有抑郁症的躁狂患者（44%）的躁狂评分高于不抑郁的躁狂患者。伴有抑郁和躁狂的患者的总体治疗结果明显较差，尽管他们的抑郁评分在锂治疗期间有所改善。
The effects of lithium treatment and prediction of response in 18 manic patients were studied as part of the National Institute of Mental Health Collaborative Study of the Psychobiology of Depression. Patients were rated using the Mania Diagnostic and Severity Scale (MADS) and an additional battery of behavioral constructs developed for measurement of state and drug response in depressed patients. About 67% of the patients had good treatment outcome after 26 days of lithium treatment. Responders did not differ from nonresponders before treatment with respect to delusions, hallucinations, or irritable-paranoid symptoms. Nonresponders were rated as more anxious than responders before treatment and had higher scores on the Hamilton Rating Scale for Depression. Improvement on the MADS, however, did not correlate with pretreatment behavioral ratings. Patients with relatively high ratings for aspects of behavior not specific to mania tended to improve in these regardless of change in MADS score. Manic patients who were also depressed (44%) had higher mania ratings than manic patients who were not depressed. Patients with concomitant depression and mania had significantly worse overall treatment outcome, although their depression ratings improved during lithium treatment.