Polymeric drugs: Advances in the development of pharmacologically active polymers.
Polymeric drugs: Advances in the development of pharmacologically active polymers.
复制标题
DOI：
10.1016/j.jconrel.2015.09.043
复制
发表时间：
2015-12-10
期刊：
影响因子：
--
通讯作者：
Oupický D
中科院分区：
文献类型：
--
作者：
Li J;Yu F;Chen Y;Oupický D
合成聚合物在药物发现和开发中发挥着关键作用。目前药用高分子的研究和应用主要集中在其作为赋形剂和其他药物的惰性载体的功能。本文综述了聚合物作为药物活性剂的替代药物用途的最新进展。重点放在与其大分子特征和探索生物学相关的多价过程的能力相关的聚合物药物的好处。我们讨论了聚合物药物作为螯合剂、抗菌剂、抗病毒药、抗癌剂和抗炎剂的主要治疗用途。
Synthetic polymers play a critical role in pharmaceutical discovery and development. Current research and applications of pharmaceutical polymers are mainly focused on their functions as excipients and inert carriers of other pharmacologically active agents. This review article surveys recent advances in alternative pharmaceutical use of polymers as pharmacologically active agents known as polymeric drugs. Emphasis is placed on the benefits of polymeric drugs that are associated with their macromolecular character and their ability to explore biologically relevant multivalency processes. We discuss the main therapeutic uses of polymeric drugs as sequestrants, antimicrobials, antivirals, and anticancer and anti-inflammatory agents.