Growth factors and the development and function of the reproductive organs.
Growth factors and the development and function of the reproductive organs.
复制标题
生长因子和生殖器官的发育和功能。
DOI：
10.1055/s-0028-1108004
复制
发表时间：
2009
影响因子：
2.7
通讯作者：
Conti,Marco
中科院分区：
文献类型：
--
作者：
Guidice,LindaC;Conti,Marco
Together with well established endocrine regulations that involve the hypothalamic-pituitary-gonadal axis, investigation spanning the last two decades has solidified the concept that additional layers of local controls are essential for gonadal function. In both the female and male gonads, these regulations rely on local secretion of growth factors functioning in a short and medium range within the gonad itself. These regulations support the dialogue between somatic and germ cells that begins when the bipotential gonadal primordium is colonized by primordial germ cells. This function continues at the time of formation of follicles and seminiferous tubules, as well as in the adult, where it is essential for the production of fully functional male and female gametes. Paracrine regulations involving growth factors are equally important after fertilization, when the embryo begins its interaction with the uterus at the time of implantation.The present issue provides an overview of how growth factor signaling is implicated at different stages of the life cycle of the male and female gonads. Given the broadness of the field and page constraints, this compendium could not be a comprehensive review of all growth factors involved in reproduction. Instead, we have elected to focus on areas where regulatory
