Feasibility trial of an early therapy in perinatal stroke (eTIPS).
Feasibility trial of an early therapy in perinatal stroke (eTIPS).
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DOI：
10.1186/s12883-018-1106-4
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发表时间：
2018-07-23
期刊：
影响因子：
2.6
通讯作者：
Rapley T
中科院分区：
文献类型：
--
作者：
Basu AP;Pearse J;Watson R;Dulson P;Baggaley J;Wright B;Howel D;Vale L;Mitra D;Embleton N;Rapley T
围产期中风（PS）影响多达1/2300的婴儿，并经常导致单侧脑瘫（UCP）。受单侧出血性实质梗死（HPI）影响的早产儿也有发生UCP的风险。到目前为止，还没有标准化的早期治疗方法，但早期干预可能是非常有效的，通过积极影响发育中的神经系统（包括皮质脊髓束）中活动依赖的可塑性过程。我们的目的是测试“围产期卒中早期治疗”（eTIPS）干预的可行性和可接受性，旨在最终改善运动预后。设计：可行性试验，英格兰东北部，2015年8月- 2017年9月。参与者是患有PS或HPI的婴儿，他们的照顾者和治疗师。干预包括父母提供的横向治疗方法，从足月等效年龄开始，持续到6个月矫正年龄。结果测量是干预的可行性（招募率和保留率）和可接受性（父母问卷，包括沃里克-爱丁堡心理健康量表（WEBWMS），定性观察和对父母和治疗师的深入访谈）。我们还回顾了临床影像资料，并进行了运动功能评估，包括婴儿手部评估（HAI）。还在典型发育（TD）婴儿中进行了试点评估，以提供有关其易用性和可接受性的进一步信息。在18个月的时间里，我们筛选了20名被称为PS/HPI的婴儿：14名符合纳入标准，13名参加了研究。6个月时，11人（85%）完成了最终评估。家长们很重视这种干预，认为它是可以接受和可行的。没有与干预相关的不良事件。我们招募了14名TD婴儿，其中一人在进行任何评估之前死亡，其中一人随后被发现患有影响神经发育进展的疾病：因此，我们分析了12名TD婴儿的数据至6个月。婴儿对HAI的耐受性良好，父母对其评价很高。WEBWMS的完成率很高，并没有表明参与eTIPS对父母的心理健康有任何不利影响。eTIPS干预是可行的，并为家庭所接受。我们计划在一项多中心随机对照试验中调查其疗效。ISRCTN12547427（注册请求提交于2015年5月28日，已追溯注册，2015年9月30日）。
Perinatal stroke (PS) affects up to 1/2300 infants and frequently leads to unilateral cerebral palsy (UCP). Preterm-born infants affected by unilateral haemorrhagic parenchymal infarction (HPI) are also at risk of UCP. To date no standardised early therapy approach exists, yet early intervention could be highly effective, by positively influencing processes of activity-dependent plasticity within the developing nervous system including the corticospinal tract. Our aim was to test feasibility and acceptability of an “early Therapy In Perinatal Stroke” (eTIPS) intervention, aiming ultimately to improve motor outcome. Design: Feasibility trial, North-East England, August 2015–September 2017. Participants were infants with PS or HPI, their carers and therapists. The intervention consisted of a parent-delivered lateralised therapy approach starting from term equivalent age and continuing until 6 months corrected age. The outcome measures were feasibility (recruitment and retention rates) and acceptability of the intervention (parental questionnaires including the Warwick-Edinburgh Mental Wellbeing Scale (WEBWMS), qualitative observations and in-depth interviews with parents and therapists). We also reviewed clinical imaging data and undertook assessments of motor function, including the Hand Assessment for Infants (HAI). Assessments were also piloted in typically developing (TD) infants, to provide further information on their ease of use and acceptability. Over a period of 18 months we screened 20 infants referred as PS/HPI: 14 met the inclusion criteria and 13 took part. At 6 months, 11 (85%) of those enrolled had completed the final assessment. Parents valued the intervention and found it acceptable and workable. There were no adverse events related to the intervention. We recruited 14 TD infants, one of whom died prior to undertaking any assessments and one of whom was subsequently found to have a condition affecting neurodevelopmental progress: thus, data for 12 TD infants was analysed to 6 months. The HAI was well tolerated by infants and highly valued by parents. Completion rates for the WEBWMS were high and did not suggest any adverse effect of engagement in eTIPS on parental mental wellbeing. The eTIPS intervention was feasible to deliver and acceptable to families. We plan to investigate efficacy in a multicentre randomised controlled trial. ISRCTN12547427 (registration request submitted 28/05/2015; retrospectively registered, 30/09/2015).
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影响因子：
8.3
作者：
Kitchen, Lisa;Westmacott, Robyn;deVeber, Gabrielle
通讯作者：
deVeber, Gabrielle
影响因子：
8.2
作者：
Eyre, J. A.
通讯作者：
Eyre, J. A.
DOI：
10.1207/s15374424jccp1802_8
发表时间：
1989-06-01
期刊：
JOURNAL OF CLINICAL CHILD PSYCHOLOGY
影响因子：
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作者：
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通讯作者：
MASH, EJ
影响因子：
3.8
作者：
Krumlinde-Sundholm, Lena;Ek, Linda;Eliasson, Ann-Christin
通讯作者：
Eliasson, Ann-Christin
影响因子：
8
作者：
Husson, Beatrice;Hertz-Pannier, Lucie;Chabrier, Stephane
通讯作者：
Chabrier, Stephane