Psychological reactions and quality of life in patients with posterior uveal melanoma treated with ruthenium plaque therapy or enucleation: a one year follow-up study
Psychological reactions and quality of life in patients with posterior uveal melanoma treated with ruthenium plaque therapy or enucleation: a one year follow-up study
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DOI：
10.1038/eye.2000.233
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发表时间：
2000-12-01
期刊：
影响因子：
3.9
通讯作者：
Seregard, S
中科院分区：
文献类型：
--
作者：
Brandberg, Y;Kock, E;Seregard, S
方法对1995-1996年在St Erik's眼科医院就诊的葡萄膜恶性黑色素瘤患者（99/106），分别行巩膜外照射（n = 50）和眼球摘除术（n = 49）。分别于治疗前、诊断后2个月和12个月完成医院焦虑抑郁量表、事件影响量表和EORTC QLQ-C30量表。在诊断后12个月进行疾病特异性问卷调查。组间差异进行了分析卡方，学生的t检验和ANOVA。结果大多数患者报告降低的“生活质量”（72-85%），“情绪功能”（60-74%）和“认知功能”（51-61%）。“疲劳”是最常报告的症状（61-72%），其次是“不适”（43-58%）。焦虑和抑郁症状在治疗后1年内相对频繁，但焦虑水平在治疗后第一年下降。诊断后1年，两个治疗组均报告了疾病和治疗相关问题。摘除的患者有更多的问题，外观和判断距离，而那些接受放疗的报告视力损害的程度较高。结论摘除的患者报告高水平的情绪困扰，外观和判断距离的问题，在治疗后的第一年。接受放射治疗的患者报告了相似水平的生活质量和情绪问题，但更多的问题是视力障碍。在讨论治疗方案时，应考虑到这些对疾病相关功能影响的差异。
Purpose To investigate psychological reactions and quality of life among patients with posterior uveal melanoma.Methods Consecutive patients with uveal malignant melanoma (99/106), referred to St Erik's Eye Hospital 1995-1996, treated with rutheniuim plaque radiotherapy (n = 50) or enucleation (n = 49), were included in this non-randomised prospective comparative study. Questionnaires were completed before treatment (Hospital Anxiety and Depression Scale, HAD scale) and 2 and 12 months after diagnosis including the HAD scale, the Impact of Event Scale and the EORTC QLQ-C30. A disease-specific questionnaire was included 12 months after diagnosis. Between-group differences were analysed by chi-square, Student's t-test and ANOVA.Results A majority of the patients reported reduced 'Quality of Life' (72-85%), 'Emotional functioning' (60-74%) and 'Cognitive functioning' (51-61%). 'Fatigue' was the most frequently reported symptom (61-72%) followed by 'Insomnia' (43-58%). Anxiety and depressive symptoms were relatively frequent up to 1 year after treatment, but the levels of anxiety decreased during the first year after treatment. Disease and treatment-related problems were reported in both treatment groups 1 year after diagnosis. Enucleated patients had more problems with appearance and judging distances, whereas those treated with radiotherapy reported vision impairment to a higher extent.Conclusions Enucleated patients reported high levels of emotional distress, problems with appearance and judging distances during the first year after treatment. Patients treated with radiotherapy reported similar levels of quality of life and emotional problems, but more problems with visual impairment. These differences in impact on disease-related functioning should be taken into account when treatment options are discussed.