CYCLIC AMP - A MEDIATOR OF THYROID STIMULATION BY THYROTROPIN
CYCLIC AMP - A MEDIATOR OF THYROID STIMULATION BY THYROTROPIN
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DOI：
10.1152/ajplegacy.1967.213.3.753
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发表时间：
1967-01-01
影响因子：
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通讯作者：
MCKENZIE, JM
中科院分区：
文献类型：
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作者：
BASTOMSKY, CH;MCKENZIE, JM
茶碱（一种环核苷酸磷酸二酯酶抑制剂）、环 AMP、5[image]-AMP、ADP 和 ATP 会增加甲状腺碘被 125I 标记的小鼠血液中 125I 的浓度。给予无效剂量的茶碱和阈下剂量的促甲状腺素或环AMP导致血液125I显着增加。同时给予各自无效剂量的促甲状腺素和茶碱会导致大鼠甲状腺放射性碘显着减少。茶碱可增强促甲状腺激素诱导的大鼠甲状腺与血清放射性碘化物比率的增加以及小鼠甲状腺对 131I 的摄取。环磷酸腺苷很可能介导促甲状腺素对甲状腺碘代谢主要方面的影响。
Theophylline (a cyclic-nucleotide phosphodiesterase inhibitor), cyclic AMP, 5[image]-AMP, ADP, and ATP increased the 125I concentration in the blood of mice whose thyroid iodine was labeled with 125I. Administration of ineffective doses of theophylline with subliminal doses of thyrotropin or cyclic AMP resulted in significant increases in blood-125I. Simultaneous administration of individually ineffective doses of thyrotropin and theophylline caused significant depletion of thyroid radioiodine in rats. Theophylline augmented thyrotropln-induced increases in the ratio of thyroid-to-serum radioiodide in rats and in the thyroid uptake of 131I in mice. It is probable that cyclic AMP mediates the effects of thyrotropin on the major facets of thyroid iodine metabolism.