Immunohistochemical prognostic factors in resected colorectal lung metastases using tissue microarray analysis
Immunohistochemical prognostic factors in resected colorectal lung metastases using tissue microarray analysis
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DOI：
10.1016/j.ejso.2005.12.003
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发表时间：
2006-04-01
期刊：
影响因子：
3.8
通讯作者：
Ochiai, A
中科院分区：
文献类型：
--
作者：
Shiono, S;Ishii, G;Ochiai, A
目的：肺转移性结直肠癌病变的免疫组织化学预后因素尚未得到充分研究。本研究旨在确定转移性结直肠癌的免疫组织化学预后因素。方法：我们使用组织微阵列对 86 个转移性病灶的手术标本中胰岛素样生长因子-1 受体（IGFI-R）、E-钙粘蛋白、β-连环蛋白和 p53 的表达进行免疫组织化学研究。结果：单变量分析显示 E-钙粘蛋白和膜 β-连环蛋白阳性是预后因素。 IGFI-R 和 p53 与患者的生存没有显着相关。多因素分析显示，E-cadherin表达降低、漂浮癌细胞簇气源性扩散以及血管侵犯是独立的预后因素。结论：肺转移病灶中E-cadherin表达降低是肺转移瘤切除术后生存不良的独立预测因素。 (c) 2005 年，爱思唯尔有限公司出版。
Aims: Immunohistochemical prognostic factors of pulmonary metastatic colorectal cancer lesions have not been well investigated. The study was conducted to identify the immunohistochemical prognostic factors of metastasized colorectal cancer.Methods: We immunohistochemicaly investigated the expression of insulin-like growth factor-1 receptor (IGFI-R), E-cadherin, beta-catenin, and p53 using a tissue microarray in the surgical specimens of 86 metastatic lesions.Results: The univariate analysis revealed E-cadherin and membrane beta-catenin positive to be prognostic factors. IGFI-R and p53 were not significantly associated with the patient's survival. In multivariate analysis, the reduced expression of E-cadherin, aerogenous spread with floating cancer cell clusters and vascular invasion were independent prognostic factors.Conclusions: The reduced expression of E-cadherin in the pulmonary metastatic lesions was an independent predictor of poor survival after pulmonary metastasectomy. (c) 2005 Published by Elsevier Ltd.